RNMT - RNA guanine-7 methyltransferase Gene
Also Known as MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1; N7-MTase
Species: Homo sapiens
About RNMT
This gene has 10 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues.
Summary
Enables RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
RNMT Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001308263.2 | NP_001295192.1 | mRNA cap guanine-N7 methyltransferase isoform 1 |
| NM_001378132.1 | NP_001365061.1 | mRNA cap guanine-N7 methyltransferase isoform 3 |
| NM_001378134.1 | NP_001365063.1 | mRNA cap guanine-N7 methyltransferase isoform 1 |
| NM_001378135.1 | NP_001365064.1 | mRNA cap guanine-N7 methyltransferase isoform 2 |
| NM_003799.3 | NP_003790.1 | mRNA cap guanine-N7 methyltransferase isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RNA binding |
IMP
IMP: Inferred from mutant phenotype
|
9790902 | GOA |
| enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
IDA
IDA: Inferred from direct assay
|
22099306 | GOA |
| enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
IMP
IMP: Inferred from mutant phenotype
|
9790902 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
22099306 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in 7-methylguanosine mRNA capping |
IDA
IDA: Inferred from direct assay
|
27422871 | GOA |
| involved in 7-methylguanosine mRNA capping |
IMP
IMP: Inferred from mutant phenotype
|
9790902 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of mRNA cap methyltransferase RNMT:RAMAC complex |
IDA
IDA: Inferred from direct assay
|
22099306 | GOA |
| part of mRNA capping enzyme complex |
IDA
IDA: Inferred from direct assay
|
27422871 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
9790902 | GOA |
| part of receptor complex |
IDA
IDA: Inferred from direct assay
|
23382219 | GOA |
RNMT Protein Structure
Pox_MCEL: mRNA capping enzyme (137 - 475)
- 0
- 100
- 200
- 300
- 400
- 476 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
mRNA cap guanine-N7 methyltransferase |
|
RNMT Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
RNMT | O43148 | PLEKHA3 | Homo sapiens | Q9HB20 | 32296183 | |
|
Intra
|
RNMT | O43148 | PLEKHA3 | Homo sapiens | Q9HB20 | 32296183 | |
|
Intra
|
RNMT | O43148 | PLEKHA3 | Homo sapiens | Q9HB20 | 32296183 | |
|
Intra
|
RNMT | O43148 | GMCL1 | Homo sapiens | Q96IK5 | 32296183 | |
|
Intra
|
RNMT | O43148 | GMCL1 | Homo sapiens | Q96IK5 | 32296183 | |
|
Intra
|
RNMT | O43148 | GMCL1 | Homo sapiens | Q96IK5 | 32296183 | |
|
Intra
|
RNMT | O43148 | KPNA2 | Homo sapiens | P52292 | 32296183 | |
|
Intra
|
RNMT | O43148 | KPNA2 | Homo sapiens | P52292 | 32296183 | |
|
Intra
|
RNMT | O43148 | KPNA2 | Homo sapiens | P52292 | 32296183 | |
|
Intra
|
RNMT | O43148 | KPNA6 | Homo sapiens | O60684 | 33961781 | |
|
Intra
|
RNMT | O43148 | KPNA6 | Homo sapiens | O60684 | 32296183 | |
|
Intra
|
RNMT | O43148 | KPNA6 | Homo sapiens | O60684 | 32296183 | |
|
Intra
|
RNMT | O43148 | KPNA6 | Homo sapiens | O60684 | 32296183 | |
|
Intra
|
RNMT | O43148 | RAMAC | Homo sapiens | Q9BTL3 | 30021884 | |
|
Intra
|
RNMT | O43148 | RAMAC | Homo sapiens | Q9BTL3 | 32296183 | |
|
Intra
|
RNMT | O43148 | RAMAC | Homo sapiens | Q9BTL3 | 32296183 | |
|
Intra
|
RNMT | O43148 | RAMAC | Homo sapiens | Q9BTL3 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Microphthalmia, Isolated 6 |
|
|
| Cardiomyopathy, Familial Restrictive, 1 |
|
|
| Dubowitz Syndrome |
|
|
| Hypermethioninemia |
|
|
| Wilms Tumor 1 |
|
|
| Williams-Beuren Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | RNMT | MGD | MGI:1915147 |
| Bos taurus | RNMT | VGNC | VGNC:34077 |
| Felis catus | RNMT | VGNC | VGNC:64710 |
| Rattus norvegicus | RNMT | RGD | RGD:1309242 |
| Macaca mulatta | RNMT | VGNC | VGNC:76710 |
| Others | RNMT | NCBI |