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  2. RNMT - RNA guanine-7 methyltransferase Gene

RNMT - RNA guanine-7 methyltransferase Gene

Homo sapiens

Also known as MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1; N7-MTase

Gene ID: 8731 | Gene type: protein coding

About RNMT

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,726,673-13,764,556 (from NCBI)

This gene has 10 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues.

Summary

Enables RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

RNMT Products(5)

mRNA Protein Name
NM_001308263.2 NP_001295192.1 mRNA cap guanine-N7 methyltransferase isoform 1
NM_001378132.1 NP_001365061.1 mRNA cap guanine-N7 methyltransferase isoform 3
NM_001378134.1 NP_001365063.1 mRNA cap guanine-N7 methyltransferase isoform 1
NM_001378135.1 NP_001365064.1 mRNA cap guanine-N7 methyltransferase isoform 2
NM_003799.3 NP_003790.1 mRNA cap guanine-N7 methyltransferase isoform 2

RNMT Protein Structure

Pox_MCEL

Pox_MCEL: mRNA capping enzyme (137 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

mRNA cap guanine-N7 methyltransferase

RNA (guanine-7-) methyltransferase

Related Diseases

Diseases Alias
Microphthalmia, Isolated 6

Isolated Microphthalmia 6

MCOP6

Microphthalmia, Posterior Nonsyndromic

Posterior Nonsyndromic Microphthalmia

Microphthalmia, Isolated, 6

Autosomal Recessive Posterior Microphthalmos

Posterior Non-Syndromic Microphthalmia

Microphthalmia, Isolated, Type 6

Cardiomyopathy, Familial Restrictive, 1

RCM1

Restrictive Cardiomyopathy 1

Rcm

Familial Restrictive Cardiomyopathy 1

Cardiomyopathy, Familial Restrictive 1

Cardiomyopathy, Restrictive, Familial, Type 1

Rcm-1

Dubowitz Syndrome

Dubowitz'S Syndrome

Dwarfism-Eczema-Peculiar Facies Syndrome

Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency

Deficiency Of Methionine Adenosyltransferase

Glycine N-Methyltransferase Deficiency

Met

S-Adenosylhomocysteine Hydrolase Deficiency

Gnmt Deficiency

Mat Deficiency

Methionine Adenosyltransferase Deficiency

Methioninemia

Deficiency Of Acetyl-Coa Acetyltransferase

Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor

Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus RNMT MGD MGI:1915147
Bos taurus RNMT VGNC VGNC:34077
Felis catus RNMT VGNC VGNC:64710
Rattus norvegicus RNMT RGD RGD:1309242
Macaca mulatta RNMT VGNC VGNC:76710