ENTPD3 - ectonucleoside triphosphate diphosphohydrolase 3 Gene

Also Known as HB6; CD39L3; NTPDase-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 956

About ENTPD3

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:40,387,184-40,428,744 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 7 paralogues. Broad expression in urinary bladder (RPKM 4.1), thyroid (RPKM 2.0) and 20 other tissues.

Summary

This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and Other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]

ENTPD3 Products (3)

mRNA Protein Name
NM_001248.4 NP_001239.2 ectonucleoside triphosphate diphosphohydrolase 3 isoform 1
NM_001291960.2 NP_001278889.1 ectonucleoside triphosphate diphosphohydrolase 3 isoform 1
NM_001291961.2 NP_001278890.1 ectonucleoside triphosphate diphosphohydrolase 3 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables nucleoside diphosphate phosphatase activity IDA
IDA: Inferred from direct assay
10231536 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ribonucleoside triphosphate phosphatase activity IDA
IDA: Inferred from direct assay
10231536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTPD3 Protein Structure

GDA1_CD39

GDA1_CD39: GDA1/CD39 (nucleoside phosphatase) family (55 - 474)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

ectonucleoside triphosphate diphosphohydrolase 3

  • CD39 antigen-like 3

ENTPD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ENTPD3 O75355 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra
ENTPD3 O75355 SYNE4 Homo sapiens Q8N205
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ENTPD3 Proteins

Cat. No. Product Name Accession Purity
HY-P76904 ENTPD3 Protein, Human (sf9, His) O75355 (Q44-P485) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Vasculogenic Impotence

  • Impotence, Vasculogenic
Purulent Labyrinthitis

  • Suppurative Labyrinthitis

  • Acute Suppurative Labyrinthitis

  • Bacterial Labyrinthitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04397 ENTPD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19774 Entpd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26271 Entpd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ENTPD3 VGNC VGNC:72226
Rattus norvegicus ENTPD3 RGD RGD:631326
Bos taurus ENTPD3 VGNC VGNC:28510
Mus musculus ENTPD3 MGD MGI:1321386
Canis familiaris ENTPD3 VGNC VGNC:40382
Felis catus ENTPD3 VGNC VGNC:61880
Others ENTPD3 NCBI