Bis-PEG6-NHS ester
Based on 1 Customer Validation
Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1526718-98-8
- Formula: C24H36N2O14
- Molecular Weight:576.55
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Storage:
-20°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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Cleavable Linker |
PEGs |
Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1526718-98-8
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Appearance Viscous Liquid
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Molecular Weight 576.55
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Formula C24H36N2O14
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Color Colorless to light yellow
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SMILES
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : ≥ 100 mg/mL (173.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7345 mL | 8.6723 mL | 17.3445 mL | 43.3614 mL |
| 5 mM | 0.3469 mL | 1.7345 mL | 3.4689 mL | 8.6723 mL | |
| 10 mM | 0.1734 mL | 0.8672 mL | 1.7345 mL | 4.3361 mL | |
| 15 mM | 0.1156 mL | 0.5782 mL | 1.1563 mL | 2.8908 mL | |
| 20 mM | 0.0867 mL | 0.4336 mL | 0.8672 mL | 2.1681 mL | |
| 25 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7345 mL | |
| 30 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4454 mL | |
| 40 mM | 0.0434 mL | 0.2168 mL | 0.4336 mL | 1.0840 mL | |
| 50 mM | 0.0347 mL | 0.1734 mL | 0.3469 mL | 0.8672 mL | |
| 60 mM | 0.0289 mL | 0.1445 mL | 0.2891 mL | 0.7227 mL | |
| 80 mM | 0.0217 mL | 0.1084 mL | 0.2168 mL | 0.5420 mL | |
| 100 mM | 0.0173 mL | 0.0867 mL | 0.1734 mL | 0.4336 mL |
Bis-PEG6-NHS ester Related Classifications
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