574-77-6
Chemical Structure
Papaveroline
- CAS No.: 574-77-6
- Formula:C16H13NO4
- Molecular Weight:283.28
InChIKey: MXQKCNCLQIHHJA-UHFFFAOYSA-N
SMILES: OC1=CC=C(CC2=NC=CC3=C2C=C(O)C(O)=C3)C=C1O
Biological Activity: Papaveroline is a Fyn tyrosine kinase inhibitor, Na+,K+-ATPase inhibitor with an IC50 of 0.20 mM, Mg2+-ATPase inhibitor, K+-activated pNPPase inhibitor with an IC50 of 1.51 mM, and apoptosis inducer[1][2][3]. Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues[1]. Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels[3]. Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease[3]. Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Papaveroline | Papaveroline is a Fyn tyrosine kinase inhibitor, Na+,K+-ATPase inhibitor with an IC50 of 0.20 mM, Mg2+-ATPase inhibitor, K+-activated pNPPase inhibitor with an IC50 of 1.51 mM, and apoptosis inducer. Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues. Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels. Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease. Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Bhat SS, et al. Computational Insights into Papaveroline as an In Silico Drug Candidate for Alzheimer's Disease via Fyn Tyrosine Kinase Inhibition. Molecular biotechnology. 2025 Jul;67(7):2743-2757. [Content Brief]
- [2]. Meyerson LR, et al. Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases. Neurochemical research. 1978 Apr;3(2):239-57. [Content Brief]
- [3]. Maruyama W, et al. Dopaminergic neurotoxins, 6,7-dihydroxy-1-(3', 4'-dihydroxybenzyl)-isoquinolines, cause different types of cell death in SH-SY5Y cells: apoptosis was induced by oxidized papaverolines and necrosis by reduced tetrahydropapaverolines. Neuroscience letters. 2000 Sep 15;291(2):89-92. [Content Brief]
Keywords
