Cap-specific adenosine methyltransferase

Definition:

Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally.

References:

[1]. Erdem Sendinc, et al. PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. Mol Cell. 2019 Aug 8;75(3):620-630.e9. [Content Brief]

[2]. Hanxiao Sun, et al. Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase. Cell Res. 2019 Jan;29(1):80-82. [Content Brief]

[3]. Shinichiro Akichika, et al. Cap-specific terminal N 6-methylation of RNA by an RNA polymerase II-associated methyltransferase. Science. 2019 Jan 11;363(6423):eaav0080. [Content Brief]

[4]. Konstantinos Boulias, et al. Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome. Mol Cell. 2019 Aug 8;75(3):631-643.e8. [Content Brief]

[5]. Dan Yu, et al. Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima. J Biol Chem. 2021 Jan-Jun;296:100270. [Content Brief]

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