Defensin alpha 5
Definition:
References:
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[1]. B O Schroeder, et al. Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide. Mucosal Immunol. 2015 May;8(3):661-71. [Content Brief]
[2]. Dipankar Ghosh, et al. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol. 2002 Jun;3(6):583-90. [Content Brief]
[3]. John David Spencer, et al. Human alpha defensin 5 expression in the human kidney and urinary tract. PLoS One. 2012;7(2):e31712. [Content Brief]
[4]. Cheng Wang, et al. Design of a potent antibiotic peptide based on the active region of human defensin 5. J Med Chem. 2015 Apr 9;58(7):3083-93. [Content Brief]
[5]. Bryan Ericksen, et al. Antibacterial activity and specificity of the six human {alpha}-defensins. Antimicrob Agents Chemother. 2005 Jan;49(1):269-75. [Content Brief]
[6]. Dan Xu, et al. Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity. 2018 Jun 19;48(6):1233-1244.e6. [Content Brief]
[7]. Nita H Salzman, et al. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature. 2003 Apr 3;422(6931):522-6. [Content Brief]
[8]. Mohsen Rajabi, et al. Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface. J Biol Chem. 2012 Jun 22;287(26):21615-27. [Content Brief]
[9]. Erik de Leeuw, et al. Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5. FEBS Lett. 2009 Aug 6;583(15):2507-12. [Content Brief]
[10]. D Ehmann, et al. Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3746-3751. [Content Brief]
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