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Filensin

Definition:

Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability.

References:

[1]. Jose M Chaves, et al. Human alpha A-crystallin missing N-terminal domain poorly complexes with filensin and phakinin. Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):402-408. [Content Brief]

[2]. Antal Tapodi, et al. BFSP1 C-terminal domains released by post-translational processing events can alter significantly the calcium regulation of AQP0 water permeability. Exp Eye Res. 2019 Aug;185:107585. [Content Brief]

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