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Golgi phosphoprotein 3

Definition:

Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.

References:

[1]. Michelle M Ng, et al. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. Mol Biol Cell. 2013 Mar;24(6):796-808. [Content Brief]

[2]. Kenneth L Scott, et al. GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature. 2009 Jun 25;459(7250):1085-90. [Content Brief]

[3]. Xiuping Zhou, et al. GOLPH3 regulates the migration and invasion of glioma cells though RhoA. Biochem Biophys Res Commun. 2013 Apr 12;433(3):338-44. [Content Brief]

[4]. Holly C Dippold, et al. GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell. 2009 Oct 16;139(2):337-51. [Content Brief]

[5]. Bryan Bishé, et al. Role of phosphatidylinositol 4-phosphate (PI4P) and its binding protein GOLPH3 in hepatitis C virus secretion. J Biol Chem. 2012 Aug 10;287(33):27637-47. [Content Brief]

[6]. Naomi Nakashima-Kamimura, et al. MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. J Cell Sci. 2005 Nov 15;118(Pt 22):5357-67. [Content Brief]

[7]. Mohamed F Ali, et al. Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1. J Biol Chem. 2012 Nov 16;287(47):39564-77. [Content Brief]

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