HIV Tat-specific factor 1

Definition:

Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.

References:

[1]. J B Kim, et al. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. Mol Cell Biol. 1999 Sep;19(9):5960-8. [Content Brief]

[2]. Y W Fong, et al. Stimulatory effect of splicing factors on transcriptional elongation. Nature. 2001 Dec;414(6866):929-33. [Content Brief]

[3]. Q Zhou, et al. Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. Science. 1996 Oct 25;274(5287):605-10. [Content Brief]

[4]. X Y Li, et al. The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor. Genes Dev. 1998 Oct 1;12(19):2992-6. [Content Brief]

[5]. C A Parada, et al. A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription. EMBO J. 1999 Jul 1;18(13):3688-701. [Content Brief]

[6]. A Simmons, et al. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity. 2001 Jun;14(6):763-77. [Content Brief]

[7]. Dorothée Missé, et al. Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression. AIDS. 2005 Jun 10;19(9):897-905. [Content Brief]

[8]. Y W Fong, et al. Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter. Mol Cell Biol. 2000 Aug;20(16):5897-907. [Content Brief]

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