Hyaluronidase-4

Definition:

Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.

References:

[1]. Mark J Jedrzejas, et al. Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis. Proteins. 2005 Nov 1;61(2):227-38. [Content Brief]

[2]. Tomoyuki Kaneiwa, et al. Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence. Glycobiology. 2010 Mar;20(3):300-9. [Content Brief]

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