Whipple disease

Definition:

Whipple disease (WD) is a rare chronic multi-system disease associated with the bacterium Tropheryma whipplei that is ubiquitously present in the environment. The clinical features of WD are non-specific and histological lesions in gastrointestinal system can be the major manifestations. Patients without symptoms of gastrointestinal disease might be insufficiently treated, resulting in a potentially fatal outcome such as endocarditis, neurological infection, osteoarticular infection, or uveitis.

References:

[1]. Benoit Desnues, et al. New insights into Whipple's disease and Tropheryma whipplei infections. Microbes Infect. 2010 Dec;12(14-15):1102-10. [Content Brief]

[2]. Thomas Schneider, et al. Whipple's disease: new aspects of pathogenesis and treatment. Lancet Infect Dis. 2008 Mar;8(3):179-90. [Content Brief]

[3]. V Moos, et al. Changing paradigms in Whipple's disease and infection with Tropheryma whipplei. Eur J Clin Microbiol Infect Dis. 2011 Oct;30(10):1151-8. [Content Brief]

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