SCML2 - Scm polycomb group protein like 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10389

About SCML2

Cytogenetic location: Xp22.13 Genomic coordinates (GRCh38): X:18,239,313-18,355,118 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 18 paralogues. Broad expression in testis (RPKM 5.8), adrenal (RPKM 1.8) and 19 other tissues.

Summary

This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]

SCML2 Products (1)

mRNA Protein Name
NM_006089.3 NP_006080.1 sex comb on midleg-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24358021 GOA
Biological Process GO Annotation Evidence References Source
involved in anatomical structure morphogenesis IMP
IMP: Inferred from mutant phenotype
10331946 GOA
Cellular Component GO Annotation Evidence References Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
21282530 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21282530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCML2 Protein Structure

MBT

MBT: mbt repeat (67 - 138)

MBT

MBT: mbt repeat (176 - 240)

SLED

SLED: SLED domain (354 - 468)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (629 - 695)

  • 0
  • 200
  • 400
  • 600
  • 700 a.a.
Protein Preferred Names Protein Names

sex comb on midleg-like protein 2

  • sex comb on midleg like 2

SCML2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCML2 Q9UQR0 SRGAP2B Homo sapiens A0A286YEY3
Y2H Prey Pooling
32296183
Intra
SCML2 Q9UQR0 SRGAP2B Homo sapiens A0A286YEY3
Y2H Array
32296183
Intra
SCML2 Q9UQR0 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
SCML2 Q9UQR0 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
SCML2 Q9UQR0 CDK2 Homo sapiens P24941
Anti Bait CoIP
24358021
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12517 SCML2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SCML2 VGNC VGNC:76979
Canis familiaris SCML2 VGNC VGNC:45911
Bos taurus SCML2 VGNC VGNC:34341
Rattus norvegicus SCML2 RGD RGD:1564289
Felis catus SCML2 VGNC VGNC:82309
Mus musculus SCML2 MGD MGI:1340042
Others SCML2 NCBI