FOXN4 - forkhead box N4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 121643

About FOXN4

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,277,978-109,309,284 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 2 paralogues. Restricted expression toward testis (RPKM 2.5).

Summary

Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]

FOXN4 Products (1)

mRNA Protein Name
NM_213596.3 NP_998761.2 forkhead box protein N4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22323600 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27107012 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXN4 Protein Structure

Forkhead

Forkhead: Forkhead domain (193 - 283)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 517 a.a.
Protein Preferred Names Protein Names

forkhead box protein N4

  • forkhead/winged helix transcription factor FOXN4

FOXN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FOXN4 Q96NZ1 AMY1A Homo sapiens P0DTE7
Anti Tag CoIP
33961781
Intra
FOXN4 Q96NZ1 AMY1A Homo sapiens P0DTE7
Anti Tag CoIP
28514442
Intra
FOXN4 Q96NZ1 FHL3 Homo sapiens Q13643
Validated Y2H
27107012
Intra
FOXN4 Q96NZ1 RFX2 Homo sapiens P48378
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymphedema-Distichiasis Syndrome

  • Lymphedema With Distichiasis

  • Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus

  • LPHDST

  • Distichiasis-Lymphedema Syndrome

  • Lymphedema Distichiasis Syndrome

  • Hereditary Lymphedema-Distichiasis Syndrome

  • Lymphedema Distichiasis
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05068 FOXN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FOXN4 VGNC VGNC:62342
Rattus norvegicus FOXN4 RGD RGD:1306389
Macaca mulatta FOXN4 VGNC VGNC:82146
Canis familiaris FOXN4 VGNC VGNC:40962
Mus musculus FOXN4 MGD MGI:2151057
Bos taurus FOXN4 VGNC VGNC:29097
Others FOXN4 NCBI