CSNK1G3 - casein kinase 1 gamma 3 Gene

Also Known as CSNK1G3L; CKI-gamma 3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1456

About CSNK1G3

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:123,512,177-123,617,049 (from NCBI)

This gene has 11 transcripts (splice variants), 127 orthologues and 12 paralogues. Ubiquitous expression in colon (RPKM 8.2), small intestine (RPKM 7.3) and 25 other tissues.

Summary

This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and Other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

CSNK1G3 Products (16)

mRNA Protein Name
NM_001031812.4 NP_001026982.1 casein kinase I isoform gamma-3 isoform 2
NM_001044723.2 NP_001038188.1 casein kinase I isoform gamma-3 isoform 4
NM_001270572.1 NP_001257501.1 casein kinase I isoform gamma-3 isoform 5
NM_001270573.2 NP_001257502.1 casein kinase I isoform gamma-3 isoform 6
NM_001270574.2 NP_001257503.1 casein kinase I isoform gamma-3 isoform 7
NM_001364140.2 NP_001351069.1 casein kinase I isoform gamma-3 isoform 8
NM_001364141.2 NP_001351070.1 casein kinase I isoform gamma-3 isoform 9
NM_001364143.2 NP_001351072.1 casein kinase I isoform gamma-3 isoform 10
NM_001364144.2 NP_001351073.1 casein kinase I isoform gamma-3 isoform 11
NM_001364145.2 NP_001351074.1 casein kinase I isoform gamma-3 isoform 12
NM_001364146.2 NP_001351075.1 casein kinase I isoform gamma-3 isoform 13
NM_001364147.2 NP_001351076.1 casein kinase I isoform gamma-3 isoform 14
NM_001364148.2 NP_001351077.1 casein kinase I isoform gamma-3 isoform 15
NM_001364149.2 NP_001351078.1 casein kinase I isoform gamma-3 isoform 6
NM_001364150.2 NP_001351079.1 casein kinase I isoform gamma-3 isoform 6
NM_004384.5 NP_004375.2 casein kinase I isoform gamma-3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
25500533 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK1G3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (43 - 297)

CK1gamma_C

CK1gamma_C: Casein kinase 1 gamma C terminal (328 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 447 a.a.
Protein Preferred Names Protein Names

casein kinase I isoform gamma-3

casein kinase I

CSNK1G3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSNK1G3 Q9Y6M4 CSNK1G1 Homo sapiens Q9HCP0
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sarcosinemia

  • Sarcosine Dehydrogenase Complex Deficiency

  • Sard Deficiency

  • Sardh Deficiency

  • SARCOS

  • Hypersarcosinemia

  • Sardhd

  • Demethylation Defect Of N-Methylglycine
Lissencephaly 8

  • LIS8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03250 CSNK1G3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CSNK1G3 MGD MGI:1917675
Felis catus CSNK1G3 VGNC VGNC:97392
Canis familiaris CSNK1G3 VGNC VGNC:39669
Bos taurus CSNK1G3 VGNC VGNC:27768
Rattus norvegicus CSNK1G3 RGD RGD:621408
Macaca mulatta CSNK1G3 VGNC VGNC:81384
Others CSNK1G3 NCBI