VCAN - versican Gene

Also Known as WGN; ERVR; GHAP; PG-M; WGN1; CSPG2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1462

About VCAN

Cytogenetic location: 5q14.2-q14.3 Genomic coordinates (GRCh38): 5:83,471,744-83,582,302 (from NCBI)

This gene has 12 transcripts (splice variants), 320 orthologues, 7 paralogues and is associated with 3 phenotypes. Broad expression in appendix (RPKM 45.0), placenta (RPKM 35.3) and 15 other tissues.

Summary

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

VCAN Products (4)

mRNA	Protein	Name
NM_001126336.3	NP_001119808.1	versican core protein isoform 2 precursor
NM_001164097.2	NP_001157569.1	versican core protein isoform 3 precursor
NM_001164098.2	NP_001157570.1	versican core protein isoform 4 precursor
NM_004385.5	NP_004376.2	versican core protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23601700	GOA
enables protein tyrosine phosphatase activator activity	IDA IDA: Inferred from direct assay	21976490	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glial cell migration	IDA IDA: Inferred from direct assay	18431253	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	25122765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VCAN Protein Structure

V-set

Xlink

EGF

Lectin_C

Sushi

0
600
1200
1800
2400
3000
3396 a.a.

Protein Preferred Names	Protein Names
versican core protein	chondroitin sulfate proteoglycan core protein 2

VCAN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VCAN	P13611	MMP9	Homo sapiens	P14780	Zymography	23601700
Intra	VCAN	P13611	MMP9	Homo sapiens	P14780	Comigration in Gel	23601700

Cross: Cross-species interaction Intra: Intraspecies interaction

VCAN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81789	Versican Core Protein Antibody (YA1534)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Wagner Vitreoretinopathy	Hyaloideoretinal Degeneration Of Wagner Wagner Syndrome Wagner Vitreoretinal Degeneration Erosive Vitreoretinopathy Ervr Wagner Syndrome 1 Wgn1 Wagner Disease WGVRP Vcan-Related Vitreoretinopathy Wagner Syndrome Type 1 Dominant Hyaloideoretinal Dystrophy Of Wagner Vitreoretinal Degeneration, Wagner Type Wagner'S Disease
Vcan-Related Vitreoretinopathy	Hyaloideoretinal Degeneration Of Wagner
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Pneumonic Plague	Primary Pneumonic Plague Secondary Pneumonic Plague Plague Plague, Pneumonic Plague Pneumonia Plague Of Lung Pulmonary Plague Pneumonia Due To Yersinia Pestis
Vitreoretinopathy
Septicemic Plague	Plague, Septicemic
Bubonic Plague	Black Death Plague, Bubonic Plague, Septicemic Pestis Bubonica
Aortic Aneurysm	Aortic Rupture Thoracoabdominal Aortic Aneurysm, Ruptured Ruptured Aortic Aneurysm Aortic Aneurysms Aortic Aneurysm Without Mention Of Rupture Nos Ruptured Abdominal Aortic Aneurysm Aortic Aneurysm, Ruptured Ruptured Thoracic Aortic Aneurysm
Vitreous Syneresis	Vitreous Degeneration
Androgenic Alopecia	Androgenetic Alopecia Alopecia Androgenetica, Male Pattern Baldness
Telogen Effluvium
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Stickler Syndrome	Arthroophthalmopathy Hereditary Arthro-Ophthalmo-Dystrophy Hereditary Arthro-Ophthalmopathy Stickler Dysplasia Hereditary Progressive Arthroophthalmopathy Stickler Syndrome, Type 1
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15619	VCAN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19652	Vcan Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26145	Vcan Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VCAN	VGNC	VGNC:48241
Bos taurus	VCAN	VGNC	VGNC:36778
Felis catus	VCAN	VGNC	VGNC:66931
Mus musculus	VCAN	MGD	MGI:102889
Rattus norvegicus	VCAN	RGD	RGD:619940
Macaca mulatta	VCAN	VGNC	VGNC:79445
Others	VCAN	NCBI