HCAR2 - hydroxycarboxylic acid receptor 2 Gene

Also Known as HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 338442

About HCAR2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,701,293-122,703,357 (from NCBI)

This gene has 1 transcript (splice variant), 168 orthologues and 15 paralogues.

Summary

Predicted to enable nicotinic acid receptor activity. Involved in neutrophil apoptotic process and positive regulation of neutrophil apoptotic process. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

HCAR2 Products (1)

mRNA Protein Name
NM_177551.4 NP_808219.1 hydroxycarboxylic acid receptor 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in neutrophil apoptotic process IDA
IDA: Inferred from direct assay
17932499 GOA
involved in positive regulation of neutrophil apoptotic process IDA
IDA: Inferred from direct assay
17932499 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
17932499 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCAR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 294)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
Protein Preferred Names Protein Names

hydroxycarboxylic acid receptor 2

  • G protein-coupled receptor HM74a

  • G-protein coupled receptor 109A

  • G-protein coupled receptor HM74A

  • hydroxy-carboxylic acid receptor 2

  • niacin receptor 1

  • nicotinic acid receptor

Related Diseases

Diseases Alias
Pellagra

  • Niacin Deficiency

  • Niacin-Tryptophan Deficiency

  • Pellagroid Syndrome
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diversion Colitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-30216A Leucic acid 98.38% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HCAR2 RGD RGD:727952
Mus musculus HCAR2 MGD MGI:1933383