Pik3c2a - phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Gene
Species: Rattus norvegicus
About Pik3c2a
This gene has 1 transcript (splice variant), 222 orthologues, 9 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 23.7), Lung (RPKM 188.6) and 9 other tissues.
Summary
Predicted to enable clathrin binding activity and phosphatidylinositol 3-kinase activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase signaling; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to act upstream of or within autophagosome organization; cellular response to starvation; and negative regulation of zinc ion transmembrane transport. Predicted to be located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Pik3c2a Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001108500.1 | NP_001101970.1 | phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha |
Pik3c2a Protein Structure
PI3K_rbd: pfam00794 (420 - 513)
C2A_PI3K_class_II: cd04012 (677 - 849)
PI3Ka_II: cd00869 (870 - 1038)
PI3Kc_C2_alpha: cd05176 (1043 - 1395)
PX_PI3K_C2_alpha: cd07289 (1426 - 1534)
C2B_PI3K_class_II: cd08381 (1560 - 1681)
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- 1687 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha |
|