PIK3C2A - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Gene

Also Known as CPK; OCSKD; PI3-K-C2A; PI3K-C2alpha; PI3K-C2-alpha; PI3-K-C2(ALPHA)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5286

About PIK3C2A

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,086,575-17,207,986 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 18.0), testis (RPKM 13.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by Insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

PIK3C2A Products (6)

mRNA	Protein	Name
NM_001321378.2	NP_001308307.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 1
XM_047427128.1	XP_047283084.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2
NM_001321380.2	NP_001308309.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 2
NM_002645.4	NP_002636.2	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 1
XM_047427127.1	XP_047283083.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1
NM_001386870.1	NP_001373799.1	phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	9337861	GOA
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA IDA: Inferred from direct assay	9337861	GOA
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA IDA: Inferred from direct assay	9337861	GOA
enables clathrin binding	IDA IDA: Inferred from direct assay	11239472	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	21081650	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	28910396	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	26175229	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	10766823	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21081650	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10766823	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	10766823	GOA
located in vesicle	IDA IDA: Inferred from direct assay	21081650	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3C2A Protein Structure

PI3K_rbd

PI3K_C2

PI3Ka

PI3_PI4_kinase

0
300
600
900
1200
1500
1686 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	C2-containing phosphatidylinositol kinase phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha phosphoinositide 3-kinase-C2-alpha phosphoinositide-3-kinase, class 2, alpha polypeptide ptdIns-3-kinase C2 subunit alpha

Related Diseases

Diseases	Alias
Acute Anterolateral Myocardial Infarction	Acute Myocardial Infarction Of Anterolateral Wall
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Endocarditis
Necrotizing Fasciitis	Fasciitis, Necrotizing
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Exanthem	Exanthema Rash Rashes
Pyomyositis	Tropical Pyomyositis Myositis Purulenta Tropica Myositis Tropicans Pm Suppurative Myositis Purulent Myositis
Gas Gangrene	Myonecrosis Gas Bacillus Infection Gas Gangrene Due To Clostridia Clostridial Myonecrosis Clostridial Cellulitis
Muscular Lipidosis	Lipid Storage Myopathy
Posteroinferior Myocardial Infarction
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Ectopic Pregnancy	Eccyesis Pregnancy Ectopic Pregnancy, Ectopic Ectopic Pregnancies Extrauterine Gestation Or Pregnancy Extrauterine Pregnancy Ep - [Ectopic Pregnancy] Ectopic Mole Aborted Ectopic Pregnancy Ruptured Ectopic Pregnancy
Miyoshi Muscular Dystrophy	Distal Myopathy Distal Muscular Dystrophy Miyoshi Myopathy Distal Myopathies Dystrophy, Muscular, Miyoshi Myopathy, Distal Distal Muscular Dystrophies
Hemopneumothorax	Haemopneumothorax
Muscle Tissue Disease
Quadriplegia	Tetraplegia Tetraplegias
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Extrinsic Cardiomyopathy
Inflammatory And Toxic Neuropathy
Erysipelas
Compartment Syndrome	Compartment Syndromes Compartmental Syndrome
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Sarcoid Meningitis	Meningitis In Sarcoidosis
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Rectum Neuroendocrine Neoplasm	Neuroendocrine Tumor Of Rectum Neuroendocrine Tumor Of The Rectum Net Of The Rectum Rectal Net Rectal Neuroendocrine Tumor Rectal Neuroendocrine Neoplasm
Myopathy	Muscular Diseases Myopathies
Aspiration Pneumonia	Pneumonia, Aspiration Pneumonia Aspiration Aspiration Pneumonitis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Hypokalemia	Potassium Deficiency Potassium Deficiency Disorder Hypopotassemia Potassium Potassium [K] Deficiency Hypokalaemic Syndrome Hypopotassaemia Hypopotassaemia Syndrome Hypokalaemic Potassium Depletion
Disseminated Intravascular Coagulation	Defibrination Syndrome Dic Diffuse Or Disseminated Intravascular Coagulation Fibrinolytic Purpura Consumption Coagulopathy Diffuse Intravascular Coagulation Dic - [Disseminated Intravascular Coagulation] Disseminated Intravascular Coagulopathy Fibrinolysis Nos Thrombolytic Purpura
Muscular Dystrophy, Becker Type	Becker Muscular Dystrophy BMD Benign Pseudohypertrophic Muscular Dystrophy Benign Congenital Myopathy Becker Dystrophinopathy Becker'S Muscular Dystrophy Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type Muscular Dystrophy Becker Dystrophy, Muscular, Becker Type Dystrophinopathy Becker Dystrophy Becker Type Dystrophy Bmd - [Becker Muscular Dystrophy]
Diabetes Mellitus, Ketosis-Prone	Diabetic Ketoacidosis KPD Diabetes Mellitus, Ketosis-Prone, Susceptibility To Ketosis-Prone Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetic Ketoacidosis Nos Dka - [Diabetic Ketoacidosis] Nos Dka - [Diabetic Ketoacidosis] Without Coma Dka - [Diabetic Ketoacidosis] With Coma
Muscular Disease
Dermatomyositis	Amyopathic Dermatomyositis Dermatopolymyositis Adult Dermatomyositis Polymyositis With Skin Involvement Adult Type Dermatomyositis Petges-Clejat Syndrome
Posterior Myocardial Infarction
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Myringitis Bullosa Hemorrhagica	Bullous Myringitis
Cutis Laxa, Autosomal Recessive, Type Iiia	ARCL3A De Barsy Syndrome A Aldh18a1-Related De Barsy Syndrome Progeroid Syndrome Of De Barsy Autosomal Recessive Cutis Laxa Type Iiia P5cs Deficiency De Barsy Syndrome Cutis Laxa, Corneal Clouding, And Mental Retardation Delta-1-Pyrroline 5-Carboxylate Synthetase Deficiency Neurocutaneous Syndrome, Bicknell Type Cutis Laxa Corneal Clouding Mental Retardation Progeroid Syndrome De Barsy Type Cutis Laxa, Autosomal Recessive, 3a Cutis Laxa Autosomal Recessive Type Iiia Developmental Delay-Choreoathetosis-Joint Dislocation-Lax Skin Neurocutaneous Syndrome Bicknell Type Corneal Clouding Cutis Laxa Mental Retardation
Osteogenesis Imperfecta, Type Xviii	OI18 Osteogenesis Imperfecta Type 18 Osteogenesis Imperfecta, Type 18 Osteogenesis Imperfecta 18
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Toxic Myocarditis
Anterior Compartment Syndrome
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Neuroleptic Malignant Syndrome
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Childhood Type Dermatomyositis	Juvenile Dermatomyositis Juvenile Dm Childhood Dermatomyositis Amyopathic Dermatomyositis Adm Dermatomyositis Sine Myositis Dermatomyositis, Childhood Type
Coronary Artery Vasospasm	Coronary Vasospasm Coronary Artery Spasm
Myotonic Dystrophy 1	Myotonic Dystrophy Dystrophia Myotonica Steinert Disease Myotonic Dystrophy Type 1 Myotonia Atrophica DM1 Congenital Myotonic Dystrophy Myotonia Dystrophica Steinert Myotonic Dystrophy Dystrophia Myotonica 1 Dm Steinert'S Disease Steinert Myotonic Dystrophy Syndrome Myotonic Dystrophy Of Steinert Dystrophia Myotonica Type 1 Myotonic Dystrophy Congenital Dystrophy, Myotonic, Type 1 Dm - [Dystrophia Myotonica] Myotonic Muscular Dystrophy
Dengue Disease	Dengue Fever Dengue Df Dengue Shock Syndrome Dengue Virus Infection Breakbone Fever Classic Dengue Classical Dengue Dengue Hemorrhagic Fever Hemorrhagic Dengue Philippine Hemorrhagic Fever Singapore Hemorrhagic Fever Thai Hemorrhagic Fever Severe Dengue Dengue Fever Without Warning Signs Dengue Haemorrhagic Fever Grade 1 Dengue Haemorrhagic Fever Without Warning Signs Bangkok Haemorrhagic Fever Singapore Haemorrhagic Fever Thailand Haemorrhagic Fever Southeast Asia Haemorrhagic Fever Dhf -[Dengue Haemorrhagic Fever] Dengue Fever With Warning Signs Dengue Haemorrhagic Fever With Warning Signs Dengue Haemorrhagic Fever Grade 2 Philippine Haemorrhagic Fever
Spastic Paraplegia 9b, Autosomal Recessive	SPG9B Autosomal Recessive Complex Spastic Paraplegia Type 9b Hereditary Spastic Paraplegia 9b Autosomal Recessive Spastic Paraplegia 9b Autosomal Recessive Spastic Paraplegia Type 9b Ar-Spg9b
Metabolic Acidosis
Left Bundle Branch Hemiblock	Left Bundle Branch Block Left Bundle-Branch Block
Angina Pectoris	Prinzmetal'S Variant Angina Prinzmetal Angina Variant Angina Angina Angina Inversa Prinzmetal'S Angina Coronary Artery Vasospasm Angina Pectoris, Variant Variant Angina Pectoris Vasospastic Angina Angor Pectoris Anginal Syndrome Ischaemic Chest Pain Angina Pectoris Syndrome Angina Syndrome Cardiac Angina Syndrome Ap - [Angina Pectoris] Angina Nos Ap - [Angina Pectoris] Syndrome Ischaemic Heart Disease With Angina Heart Angina Chest Angina Angina Attack Anginal Cardiopathy Coronary Pain Nos
Exophthalmic Ophthalmoplegia
Coronary Stenosis	Coronary Artery Stenosis
Sarcocystosis	Sarcosporidiosis Sarcosporidiasis
Crimean-Congo Hemorrhagic Fever	Crimean Hemorrhagic Fever Cchf Congo Hemorrhagic Fever Hemorrhagic Fever, Crimean Chf Congo Virus Congo-Crimean Hemorrhagic Fever Congo Fever Hemorrhagic Fever Crimean-Congo Cchf - [Crimean-Congo Haemorrhagic Fever] Kara Mikh Typhoid Fever Xīnjiāng Haemorrhagic Fever
Pericardium Disease
Malignant Hyperthermia	Anesthesia Related Hyperthermia Malignant Hyperpyrexia Due To Anesthesia Hyperpyrexia, Malignant Hyperthermia, Malignant Malignant Hyperpyrexia Mhs Malignant Fever
Lateral Myocardial Infarction
Mutism
Myoglobinuria
Myxedema
Speech Disorder	Speech Disorders
Echolalia
Pulmonary Edema
Anteroseptal Myocardial Infarction
Ornithosis	Psittacosis Chlamydial Pneumonia Chlamydia Psittaci Infection Chlamydia Psittaci
Hypothyroidism	Thyroid Diseases Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Disease Thyroid Dysfunction
Acute Kidney Failure	Acute Renal Failure Renal Failure Acute Acute Kidney Injury Kidney Failure, Acute Pre-Renal Acute Kidney Injury Nontraumatic Acute Kidney Injury Aki - [Acute Kidney Injury] Arf - [Acute Kidney Failure] Acute Kidney Disease Acute Kidney Impairment Acute Ischaemic Renal Failure Acute Hypoxic Kidney Failure Acute Kidney Shutdown Acute Renal Oedema Acute Renal Impairment Acute Kidney Collapse Acute Necrotising Kidney Acute Renal Suppression
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Isolated Elevated Serum Creatine Phosphokinase Levels	Elevated Serum Cpk Idiopathic Hyperckemia Isolated Hyperckemia Elevated Serum Creatine Phosphokinase H-Ck Idiopathic Persistent Elevation Of Serum Creatine Kinase
Cardiogenic Shock	Shock Cardiogenic Shock, Cardiogenic
Granulomatous Myositis
Ischemia	Acute Coronary Syndrome
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration	Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration MECRCN Rhabdomyolysis
Cardiac Tamponade	Pericardial Tamponade Rose'S Tamponade
Diabetes Mellitus	Diabetes
Status Asthmaticus	Asthma With Status Asthmaticus Severe Asthma Attack
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Bacterial Meningitis	Meningitis, Bacterial Meningitis Bacterial Bm - [Bacterial Meningitis] Leptomeningitis Bacterial Pachymeningitis Bacterial Arachnoiditis Bacterial
Creatine Phosphokinase, Elevated Serum	Hyperckemia, Idiopathic Cpk, Elevated Serum Hyperckmia HYPCK
Oculoskeletodental Syndrome	OCSKD Cataracts, Early-Onset, With Skeletal And Dental Anomalies Oculocerebrodental Syndrome Oculo-Cerebro-Dental Syndrome
Breast Juvenile Papillomatosis	Juvenile Papillomatosis Of The Breast
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Lung Mixed Small Cell And Squamous Cell Carcinoma	Combined Small And Large Cell Lung Cancer Mixed Small Cell And Squamous Cell Carcinoma Of Lung Small Cell And Large Cell Carcinoma Of The Lung Small Cell And Squamous Cell Carcinoma Of The Lung
Polymyositis	Pm - [Polymyositis]
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Leptospirosis	Fort Bragg Fever Weil Disease Leptospirosis Icterohaemorrhagica Nanukayami Fever Canicola Fever Hemorrhagic Jaundice Mud Fever Stuttgart Disease Swamp Fever Rat Catcher'S Yellows Spirochetal Jaundice Weil'S Disease Cane-Cutter Fever Icterohemorrhagic Fever Rice-Field Fever Swineherd'S Disease Weil Syndrome Nanukayami Canine Leptospirosis Equine Infectious Anemia Leptospirosis Canicola Fever Due To Leptospira Autumnalis Gikiyami Leptospira Interrogans Autumnalis Infection Leptospira Interrogans Canicola Infection Leptospira Interrogans Hebdomadis Infection Leptospira Interrogans Pomona Infection Nanukayami Disease Pretibial Fever Seven-Day Fever Eia - [Equine Infectious Anaemia] Leptospira Interrogans Infection
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Pericardial Effusion	Noninflammatory Pericardial Effusion Pericardium Effusion
Subendocardial Myocardial Infarction
Spondylolisthesis	Slipped Vertebrae Acquired Spondylolisthesis
Atrioventricular Block	Av Block
Raynaud Disease	Raynaud'S Disease Raynaud Phenomenon Raynaud'S Syndrome Raynaud'S Cold Fingers, Hereditary Raynaud'S Phenomenon Raynaud'S Disease/Phenomenon Raynauds Syndrome Raynauds Phenomenon Secondary Raynaud'S Phenomenon Raynaud Syndrome
Acute Kidney Tubular Necrosis	Acute Tubular Necrosis Acute Renal Failure With Tubular Necrosis Acute Tubule Necrosis Acute Renal Failure With Lesion Of Tubular Necrosis Atn - Acute Tubular Necrosis Tubular Necrosis Acute Kidney Tubular Necrosis, Acute Acute Renal Tubular Necrosis Acute Tubular Nephrosis Ischaemic Acute Tubular Necrosis Ischaemic Tubular Necrosis Kidney Tubular Necrosis Lower Nephron Nephrosis Necrotising Renal Oedema Renal Tubular Necrosis Toxic Tubular Necrosis Tubular Kidney Necrosis Tubular Necrosis Nos Tubular Nephrosis
Critical Illness Polyneuropathy	Polyneuropathy, Critical Illness
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Anuria	Suppression Of Urinary Secretion
Inferior Myocardial Infarction	Inferior Wall Myocardial Infarction
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Pleural Lipoma	Lipoma Of Pleura
Trichinosis	Trichinellosis Human Trichinellosis Trichiniasis Trichinella Spiralis Infection Infection With Trichinella Trichinelliasis Trichinella Spiralis Infestation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112608	CHMFL-PI3KD-317	Inhibitor	98.04%	Unkown
HY-RS10511	PIK3C2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10512	Pik3c2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10513	Pik3c2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PIK3C2A	MGD	MGI:1203729
Felis catus	PIK3C2A	VGNC	VGNC:68850
Macaca mulatta	PIK3C2A	VGNC	VGNC:75992
Canis familiaris	PIK3C2A	VGNC	VGNC:44551
Rattus norvegicus	PIK3C2A	RGD	RGD:1310389
Bos taurus	PIK3C2A	VGNC	VGNC:106866
Others	PIK3C2A	NCBI