CDON - cell adhesion associated, oncogene regulated Gene

Also Known as CDO; Ihog; CDON1; HPE11; ORCAM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50937

About CDON

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,956,821-126,063,352 (from NCBI)

This gene has 20 transcripts (splice variants), 202 orthologues, 36 paralogues and is associated with 9 phenotypes. Broad expression in thyroid (RPKM 12.5), ovary (RPKM 11.8) and 17 other tissues.

Summary

This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]

CDON Products (3)

mRNA	Protein	Name
NM_001243597.2	NP_001230526.1	cell adhesion molecule-related/down-regulated by oncogenes isoform 1 precursor
NM_001378964.1	NP_001365893.1	cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor
NM_016952.5	NP_058648.4	cell adhesion molecule-related/down-regulated by oncogenes isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11782431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDON Protein Structure

Ig_2

I-set

fn3

0
200
400
600
800
1000
1200
1287 a.a.

Protein Preferred Names	Protein Names
cell adhesion molecule-related/down-regulated by oncogenes	Cdon homolog

CDON Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDON	Q4KMG0	ABL1	Homo sapiens	P00519	Anti Bait CoIP	19470755
Intra	CDON	Q4KMG0	PTCH1	Homo sapiens	Q13635	Anti Bait CoIP	21802063

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDON Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74255	CDO Protein, Human (HEK293, His)	Q4KMG0-1 (D26-D963)	≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Holoprosencephaly 11	HPE11 Holoprosencephaly-11 Holoprosencephaly, Type 11
Pituitary Stalk Interruption Syndrome	Ectopic Neurohypophysis Psis
Septopreoptic Holoprosencephaly	Septopreoptic Hpe
Midline Interhemispheric Variant Of Holoprosencephaly	Mih Mih Type Hpe Mihf Mihv Middle Interhemispheric Fusion Variant Middle Interhemispheric Variant Of Holoprosencephaly Syntelencephaly
Lobar Holoprosencephaly
Alobar Holoprosencephaly
Microform Holoprosencephaly	Hpe, Minor Form Hpe-L Holoprosencephaly, Minor Form Holoprosencephaly-Like Microform Hpe
Semilobar Holoprosencephaly
Coloboma Of Macula	Coloboma Congenital Ocular Coloboma Microphthalmia, Isolated, With Coloboma Agenesis Of Macula Hereditary Macular Coloboma Ocular Coloboma Coloboma Of Eye Macular Coloboma Uveoretinal Coloboma
Coloboma, Ocular, Autosomal Dominant	Coloboma, Ocular Coloboma Of Iris, Choroid, And Retina Coi Coloboma, Uveoretinal COAD Ocular Coloboma Uveoretinal Coloboma Chronic Obstructive Airway Disease
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Solitary Median Maxillary Central Incisor	SMMCI Fused Incisors Single Upper Central Incisor Single Central Maxillary Incisor Single Median Maxillary Central Incisor Solitary Median Maxillary Central Incisor Syndrome Incisors Fused Incisors, Fused
Generalized Epilepsy With Febrile Seizures Plus, Type 9	GEFSP9 Gefs+9 Generalized Epilepsy With Febrile Seizures Plus 9 Gefs+, Type 9 Generalised Epilepsy With Febrile Seizures Plus 9 Generalised Epilepsy With Febrile Seizures Plus Type 9 Generalized Epilepsy With Febrile Seizures Plus Type 9 Gefs+ Type 9 Epilepsy, Generalized, With Febrile Seizures Plus, Type 9
Brachydactyly, Type A1	Brachydactyly Type A1 BDA1 Farabee-Type Brachydactyly Farabee Type Brachydactyly Brachydactyly Farabee Type Brachydactyly, Farabee Type Brachydactyly A1 Brachydactyly
Seckel Syndrome 5	SCKL5 Seckel Syndrome, Type 5
Holoprosencephaly 4	HPE4 Holoprosencephaly-4 Holoprosencephaly, Type 4
Myopathy, Congenital, Compton-North	Compton-North Congenital Myopathy MYPCN Congenital Lethal Myopathy, Compton-North Type
Megaesophagus	Esophageal Achalasia
Multiple Benign Circumferential Skin Creases On Limbs	Ccsf Circumferential Skin Creases, Kunze Type Congenital Circumferential Skin Folds Kunze-Riehm Syndrome Kunze Riehm Syndrome Michelin Tire Baby Syndrome
Fetal Alcohol Spectrum Disorder	Fetal Alcohol Spectrum Disorders Fetal Alcohol Syndrome
Culler-Jones Syndrome	Postaxial Polydactyly-Anterior Pituitary Anomalies-Facial Dysmorphism Syndrome CJS Pallister-Hall Syndrome 2, Formerly Phs2, Formerly Pallister-Hall Syndrome 2 Phs2
Greig Cephalopolysyndactyly Syndrome	GCPS Polysyndactyly With Peculiar Skull Shape Polysyndactyly With Peculiars Skull Shape Greig Syndrome Cephalopolysyndactyly Syndrome Greig Cephalo-Poly-Syndactyly Syndrome Cephalopolysyndactyly, Greig Syndrome Aarskog Syndrome
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Encephalopathy, Ethylmalonic	Ethylmalonic Encephalopathy EE Epema Syndrome Encephalopathy, Petechiae, And Ethylmalonic Aciduria Ethe1 Deficiency Eme Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Pallister-Hall Syndrome	PHS Hypothalamic Hamartomas Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly Hypothalamic Hamartoblastoma Syndrome Hamartoma Of The Hypothalamus Pallister Hall Syndrome Hall-Pallister Syndrome Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly Hamartoma, Hypothalamic
Fetal Alcohol Syndrome	Fetal Alcohol Spectrum Disorders Arbd Arnd Alcohol-Related Birth Defects Alcohol-Related Neurodevelopmental Disorder Fas Fasd Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk Alcohol Related Birth Defect Alcohol Related Neurodevelopmental Disorder Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk Dysmorphism Due To Alcohol Fetal Etoh Syndrome
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02422	CDON Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19882	Cdon Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26381	Cdon Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDON	VGNC	VGNC:60716
Bos taurus	CDON	VGNC	VGNC:27151
Canis familiaris	CDON	VGNC	VGNC:39076
Mus musculus	CDON	MGD	MGI:1926387
Rattus norvegicus	CDON	RGD	RGD:708433
Macaca mulatta	CDON	VGNC	VGNC:70961
Others	CDON	NCBI