DDX28 - DEAD-box helicase 28 Gene

Also Known as MDDX28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55794

About DDX28

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,020,916-68,023,232 (from NCBI)

This gene has 1 transcript (splice variant), 181 orthologues and 38 paralogues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]

DDX28 Products (1)

mRNA Protein Name
NM_018380.4 NP_060850.2 probable ATP-dependent RNA helicase DDX28

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables rRNA binding IDA
IDA: Inferred from direct assay
25683715 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial large ribosomal subunit assembly IMP
IMP: Inferred from mutant phenotype
25683715 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
18063578 GOA
located in ribonucleoprotein granule IDA
IDA: Inferred from direct assay
25683715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX28 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (152 - 337)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (418 - 492)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 540 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX28

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 28

Related Diseases

Diseases Alias
Spastic Paraplegia 7, Autosomal Recessive

  • SPG7

  • Hereditary Spastic Paraplegia 7

  • Spastic Paraplegia Type 7

  • Spastic Paraplegia 7

  • Hereditary Spastic Paraplegia, Paraplegin Type

  • Autosomal Recessive Spastic Paraplegia 7

  • Hereditary Spastic Paraplegia Paraplegin Type

  • Spastic Paraplegia-7

  • Paraplegia, Spastic, Autosomal Recessive, Type 7

  • Spastic Paraplegia, Hereditary

  • Autosomal Recessive Hereditary Spastic Paraplegia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03642 DDX28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DDX28 VGNC VGNC:61404
Mus musculus DDX28 MGD MGI:1919236
Rattus norvegicus DDX28 RGD RGD:1311976
Canis familiaris DDX28 VGNC VGNC:39853
Macaca mulatta DDX28 VGNC VGNC:71643
Bos taurus DDX28 VGNC VGNC:27962
Others DDX28 NCBI