FNIP2 - folliculin interacting protein 2 Gene

Also Known as FNIPL; MAPO1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57600

About FNIP2

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:158,769,026-158,908,050 (from NCBI)

This gene has 6 transcripts (splice variants), 145 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 11.0), fat (RPKM 8.4) and 25 other tissues.

Summary

This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced Apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (HSP90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

FNIP2 Products (4)

mRNA	Protein	Name
NM_001323916.2	NP_001310845.1	folliculin-interacting protein 2 isoform 2
NM_001346043.2	NP_001332972.1	folliculin-interacting protein 2 isoform 3
NM_001366843.1	NP_001353772.1	folliculin-interacting protein 2 isoform 4
NM_020840.3	NP_065891.1	folliculin-interacting protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase inhibitor activity	IDA IDA: Inferred from direct assay	27353360	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18403135	GOA
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	27353360	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21209915	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	36103527	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19914239	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	25126726	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18663353	GOA
involved in regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18663353	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FNIP-folliculin RagC/D GAP	IDA IDA: Inferred from direct assay	36103527	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18403135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FNIP2 Protein Structure

FNIP_N

FNIP_M

FNIP_C

0
200
400
600
800
1000
1114 a.a.

Protein Preferred Names	Protein Names
folliculin-interacting protein 2	FNIP1-like protein

FNIP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FNIP2	Q9P278	FNIP1	Homo sapiens	Q8TF40	Anti Tag CoIP	18403135
Intra	FNIP2	Q9P278	FLCN	Homo sapiens	Q8NFG4	Anti Tag CoIP	18403135
Intra	FNIP2	Q9P278	FLCN	Homo sapiens	Q8NFG4	Anti Bait CoIP	18403135

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Birt-Hogg-Dube Syndrome	Hornstein-Knickenberg Syndrome Fibrofolliculomas With Trichodiscomas And Acrochordons BHD Birt-Hogg-Dubé Syndrome Multiple Fibrofolliculoma Familial Bhd Syndrome Birt Hogg Dube Syndrome Hornstein-Birt-Hogg-Dubé Syndrome Multiple Fibrofolliculomas
Familial Renal Oncocytoma
Multilocular Clear Cell Renal Cell Carcinoma	Cystadenocarcinoma Of Kidney Renal Cystadenocarcinoma
Oncocytoma	Oxyphilic Adenoma Follicular Adenoma, Oxyphilic Cell Adenoma, Oxyphilic Hurthle Cell Tumor Oncocytic Neoplasm
Familial Renal Papillary Carcinoma	Hereditary Papillary Renal Carcinoma Papillary Renal Cancer Hereditary
Leiomyoma Cutis	Cutaneous Leiomyoma Leiomyoma Of The Skin
Dermis Tumor	Dermis Tumour Neoplasm Of Dermis Tumor Of Dermis Tumour Of Dermis
Pneumothorax, Primary Spontaneous	Primary Spontaneous Pneumothorax Spontaneous Pneumothorax Familial Spontaneous Pneumothorax PSP Pneumothorax
Hereditary Renal Cell Carcinoma
Renal Oncocytoma	Oncocytoma, Renal Oncocytoma Of Kidney Renal Epithelial Oncocytic Tumor Oncocytoma Kidney Oncocytoma Renal Kidney Oncocytoma
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05024	FNIP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FNIP2	VGNC	VGNC:100228
Mus musculus	FNIP2	MGD	MGI:2683054
Rattus norvegicus	FNIP2	RGD	RGD:1562174
Canis familiaris	FNIP2	VGNC	VGNC:40936
Bos taurus	FNIP2	VGNC	VGNC:29069
Felis catus	FNIP2	VGNC	VGNC:62326
Others	FNIP2	NCBI