DRC1 - dynein regulatory complex subunit 1 Gene

Also Known as CILD21; C2orf39; CCDC164

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92749

About DRC1

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,401,920-26,456,711 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues, 1 paralogue and is associated with 4 phenotypes. Restricted expression toward testis (RPKM 14.3).

Summary

This gene encodes a central component of the nexin-dynein complex (N-DRC), which regulates the assembly of ciliary dynein. Mutations in this gene can cause ciliary dyskinesia. [provided by RefSeq, Aug 2015]

DRC1 Products (1)

mRNA Protein Name
NM_145038.5 NP_659475.2 dynein regulatory complex protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
34169321 GOA
Biological Process GO Annotation Evidence References Source
involved in axonemal dynein complex assembly IMP
IMP: Inferred from mutant phenotype
23354437 GOA
involved in cilium-dependent cell motility IMP
IMP: Inferred from mutant phenotype
23354437 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRC1 Protein Structure

NYD-SP28

NYD-SP28: Sperm tail (98 - 201)

NYD-SP28_assoc

NYD-SP28_assoc: Sperm tail C-terminal domain (660 - 719)

  • 0
  • 200
  • 400
  • 600
  • 740 a.a.
Protein Preferred Names Protein Names

dynein regulatory complex protein 1

  • coiled-coil domain-containing protein 164

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 21

  • CILD21

  • Primary Ciliary Dyskinesia 21

  • Primary Ciliary Dyskinesia 21 Without Situs Inversus

  • Ciliary Dyskinesia, Primary, 21, Without Situs Inversus

  • Dyskinesia, Ciliary, Primary, 21
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Non-Syndromic Male Infertility Due To Sperm Motility Disorder

  • Non-Syndromic Male Infertility Due Asthenozoospermia
Ciliary Dyskinesia, Primary, 27

  • Primary Ciliary Dyskinesia 27

  • CILD27

  • Ciliary Dyskinesia, Primary, 27, Without Situs Inversus

  • Primary Ciliary Dyskinesia 27 Without Situs Inversus

  • Primary Ciliary Dyskinesia 27 With Or Without Situs Inversus

  • Dyskinesia, Ciliary, Primary, 27
Kartagener Syndrome

  • Kartagener'S Syndrome
Situs Inversus

  • Situs Inversus Viscerum

  • Laterality Sequence

  • Complete Transposition

  • Siv
Ciliary Dyskinesia, Primary, 4

  • Primary Ciliary Dyskinesia 4

  • CILD4

  • Ciliary Dyskinesia, Primary, 4, With Or Without Situs Inversus

  • Primary Ciliary Dyskinesia 4 With Or Without Situs Inversus

  • Primary Ciliary Dyskinesia, 4
Ciliary Dyskinesia, Primary, 8

  • Primary Ciliary Dyskinesia 8

  • CILD8

  • Ciliary Dyskinesia, Primary, 8, With Or Without Situs Inversus

  • Primary Ciliary Dyskinesia 8 With Or Without Situs Inversus
Chronic Purulent Otitis Media

  • Chronic Suppurative Otitis Media

  • Csom - [Chronic Suppurative Otitis Media]
Suppurative Otitis Media

  • Otitis Media With Effusion - Purulent

  • Purulent Otitis Media

  • Otitis Media, Suppurative
Dextrocardia

  • Heart Predominantly In Right Hemithorax

  • Heart In Right Chest

  • Right-Sided Heart

  • Congenital Dextrocardia Of Heart

  • Transposition Of Heart
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03192 CRNN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03991 DRC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20719 Drc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27230 Drc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DRC1 VGNC VGNC:28205
Macaca mulatta DRC1 VGNC VGNC:71892
Felis catus DRC1 VGNC VGNC:61623
Mus musculus DRC1 MGD MGI:2685906
Rattus norvegicus DRC1 RGD RGD:1359318
Canis familiaris DRC1 VGNC VGNC:40091
Others DRC1 NCBI