BuChE-IN-11
BuChE-IN-11 (Compound 3b-1) is an selective BuChE inhibitor with an IC50 of 0.44 μM for hBuChE. BuChE-IN-11 has high blood-brain barrier permeability and exhibits strong antioxidant activity due to its free radical scavenging properties. BuChE-IN-11 interacts with the choline binding site, acetyl binding site, and peripheral anionic site, exhibiting submicromolar BuChE inhibitory activity and preventing β-amyloid (Aβ) self-aggregation. BuChE-IN-11 holds promise for research in the field of Alzheimer's disease.
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- Formule: C28H27FN4O2
- Masse moléculaire:470.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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hBCHE 0.44 μM (IC50) |
eqBCHE |
BuChE-IN-11 (Compound 3b-1) (0.1-1 µM, 120 min) demonstrates strong antioxidant activity[1]. BuChE-IN-11 (20 μM, 48h) inhibits the aggregation of αβ1-42[1]. BuChE-IN-11 (12.5-100 μM for PC12, 25-100 μM for AML12 over 24 hours) shows no significant toxicity to PC12 and AML12 cells at concentrations below 25 μM[1]. BuChE-IN-11 exhibits good blood-brain barrier permeability (CNS+) after 18 hours, indicating its ability to cross the blood-brain barrier[1]. BuChE-IN-11 is predicted to have high gastrointestinal absorption activity and low risk of cardiac toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 and AML12 cells
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Concentration:12.5-100 μM for PC12, 25-100 μM for AML12
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Incubation Time:24 h
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Result:Only exhibited significant cytotoxicity at concentrations greater than 25 µM. At concentrations below 25 µM, BuChE-IN-11 shows no significant cytotoxicity against PC12 and AML12 cells.
Chemical Information
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Masse moléculaire 470.54
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Formule C28H27FN4O2
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SMILES
O=C(NCCC1=CNC2=C1C=CC=C2)[C@@H](NCC3=CC=C(O)C(F)=C3)CC4=CNC5=C4C=CC=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BuChE-IN-11 Related Classifications
HY-163746 Related Classifications
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