SUPT16H - SPT16 homolog, facilitates chromatin remodeling subunit Gene

Also Known as CDC68; SPT16; NEDDFAC; FACTP140; SPT16/CDC68

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11198

About SUPT16H

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,351,476-21,384,019 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 30.8), lymph node (RPKM 27.6) and 25 other tissues.

Summary

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

SUPT16H Products (1)

mRNA	Protein	Name
NM_007192.4	NP_009123.1	FACT complex subunit SPT16

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16902406	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in nucleosome disassembly	IDA IDA: Inferred from direct assay	16902406	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of FACT complex	IPI IPI: Inferred from physical interaction	16902406	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9489704	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUPT16H Protein Structure

FACT-Spt16_Nlob

Peptidase_M24

SPT16

Rtt106

0
200
400
600
800
1000
1047 a.a.

Protein Preferred Names	Protein Names
FACT complex subunit SPT16	FACT 140 kDa subunit

SUPT16H Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SUPT16H	Q9Y5B9	SSRP1	Homo sapiens	Q08945	Crosslink	30021884
Intra	SUPT16H	Q9Y5B9	SSRP1	Homo sapiens	Q08945	Anti Tag CoIP	35271311
Intra	SUPT16H	Q9Y5B9	SSRP1	Homo sapiens	Q08945	Anti Bait CoIP	16902406
Intra	SUPT16H	Q9Y5B9	MCM4	Homo sapiens	P33991	Anti Tag CoIP	16902406

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum	NEDDFAC
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14034	SUPT16H Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SUPT16H	VGNC	VGNC:65846
Macaca mulatta	SUPT16H	VGNC	VGNC:78054
Bos taurus	SUPT16H	VGNC	VGNC:35478
Rattus norvegicus	SUPT16H	RGD	RGD:1310032
Mus musculus	SUPT16H	MGD	MGI:1890948
Canis familiaris	SUPT16H	VGNC	VGNC:46989
Others	SUPT16H	NCBI