SUPT16H - SPT16 homolog, facilitates chromatin remodeling subunit Gene

Homo sapiens

Also known as CDC68; SPT16; NEDDFAC; FACTP140; SPT16/CDC68

Gene ID: 11198 | Gene type: protein coding

About SUPT16H

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,351,476-21,384,019 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 30.8), lymph node (RPKM 27.6) and 25 other tissues.

Summary

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

SUPT16H Products(1)

mRNA	Protein	Name
NM_007192.4	NP_009123.1	FACT complex subunit SPT16

SUPT16H Protein Structure

FACT-Spt16_Nlob

Peptidase_M24

SPT16

Rtt106

0
200
400
600
800
1047 a.a.

Protein Preferred Names

Protein Names

FACT complex subunit SPT16

FACT 140 kDa subunit

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum

NEDDFAC

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14034	SUPT16H Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SUPT16H	VGNC	VGNC:65846
Macaca mulatta	SUPT16H	VGNC	VGNC:78054
Bos taurus	SUPT16H	VGNC	VGNC:35478
Rattus norvegicus	SUPT16H	RGD	RGD:1310032
Mus musculus	SUPT16H	MGD	MGI:1890948
Canis familiaris	SUPT16H	VGNC	VGNC:46989

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