SAT2 - spermidine/spermine N1-acetyltransferase family member 2 Gene

Also Known as SSAT2; SSAT-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 112483

About SAT2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,626,234-7,627,876 (from NCBI)

This gene has 14 transcripts (splice variants), 98 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 97.2), duodenum (RPKM 89.6) and 25 other tissues.

Summary

Enables diamine N-acetyltransferase activity and identical protein binding activity. Involved in polyamine metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SAT2 Products (4)

mRNA Protein Name
NM_001320845.1 NP_001307774.1 thialysine N-epsilon-acetyltransferase isoform 1
NM_001320846.1 NP_001307775.1 thialysine N-epsilon-acetyltransferase isoform 2
NM_001320847.2 NP_001307776.1 thialysine N-epsilon-acetyltransferase isoform 4
NM_133491.5 NP_597998.1 thialysine N-epsilon-acetyltransferase isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables N-acetyltransferase activity IDA
IDA: Inferred from direct assay
15283699 GOA
NOT enables diamine N-acetyltransferase activity IDA
IDA: Inferred from direct assay
15283699 GOA
enables diamine N-acetyltransferase activity IDA
IDA: Inferred from direct assay
12803540 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Références Source
involved in nor-spermidine metabolic process IDA
IDA: Inferred from direct assay
12803540 GOA
NOT involved in polyamine biosynthetic process IDA
IDA: Inferred from direct assay
15283699 GOA
involved in putrescine acetylation IDA
IDA: Inferred from direct assay
12803540 GOA
NOT involved in spermidine acetylation IDA
IDA: Inferred from direct assay
15283699 GOA
involved in spermidine acetylation IDA
IDA: Inferred from direct assay
12803540 GOA
involved in spermine acetylation IDA
IDA: Inferred from direct assay
12803540 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAT2 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (70 - 145)

  • 0
  • 100
  • 170 a.a.
Protein Preferred Names Protein Names

thialysine N-epsilon-acetyltransferase

  • diamine N-acetyltransferase 2

SAT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SAT2 Q96F10 SAT1 Homo sapiens P21673
Y2H Array
32296183
Intra
SAT2 Q96F10 SAT1 Homo sapiens P21673
Anti Tag CoIP
33961781
Intra
SAT2 Q96F10 SAT1 Homo sapiens P21673
Y2H Prey Pooling
32296183
Intra
SAT2 Q96F10 SAT2 Homo sapiens Q96F10
Y2H Array
31515488
Intra
SAT2 Q96F10 POTEF Homo sapiens A5A3E0
Anti Tag CoIP
33961781
Intra
SAT2 Q96F10 PANK2 Homo sapiens Q9BZ23
Anti Tag CoIP
33961781
Intra
SAT2 Q96F10 SAT2 Homo sapiens Q96F10
Validated Y2H
32296183
Intra
SAT2 Q96F10 PANK2 Homo sapiens Q9BZ23-3
Anti Tag CoIP
28514442
Intra
SAT2 Q96F10 SAT2 Homo sapiens Q96F10
Y2H Array
32296183
Intra
SAT2 Q96F10 RYBP Homo sapiens Q8N488
TAP
24981860
Intra
SAT2 Q96F10 C1QBP Homo sapiens Q07021
Crosslink
30021884
Intra
SAT2 Q96F10 SAT2 Homo sapiens Q96F10
Y2H Array
25416956
Intra
SAT2 Q96F10 H1-2 Homo sapiens P16403
TAP
24981860
Intra
SAT2 Q96F10 NDUFA10 Homo sapiens O95299
Crosslink
30021884
Intra
SAT2 Q96F10 SMR3B Homo sapiens P02814
TAP
24981860
Intra
SAT2 Q96F10 SAT2 Homo sapiens Q96F10
Y2H Prey Pooling
32296183
Intra
SAT2 Q96F10 SMC1A Homo sapiens Q14683
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS12456 SAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13220 SLC38A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22042 Slc38a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28559 Slc38a2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SAT2 VGNC VGNC:99444
Macaca mulatta SAT2 VGNC VGNC:77086
Bos taurus SAT2 VGNC VGNC:34297
Canis familiaris SAT2 VGNC VGNC:45874
Mus musculus SAT2 MGD MGI:1916465
Rattus norvegicus SAT2 RGD RGD:1307869
Others SAT2 NCBI