H1-2 - H1.2 linker histone, cluster member Gene

Also Known as H1C; H1.2; H1F2; H1s-1; HIST1H1C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3006

About H1-2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,055,740-26,056,470 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-2 Products (1)

mRNA Protein Name
NM_005319.4 NP_005310.1 histone H1.2
Molecular Function GO Annotation Evidence References Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
15911621 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22720776 GOA
Cellular Component GO Annotation Evidence References Source
located in euchromatin IDA
IDA: Inferred from direct assay
15911621 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21383955 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-2 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (38 - 109)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

histone H1.2

  • H1 histone family, member 2

H1-2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H1-2 P16403 H2BC21 Homo sapiens Q16778 30021884
Intra
H1-2 P16403 H2AC21 Homo sapiens Q8IUE6 30021884
Intra
H1-2 P16403 H2AC21 Homo sapiens Q8IUE6 33961781
Intra
H1-2 P16403 DDX21 Homo sapiens Q9NR30 33961781
Intra
H1-2 P16403 FTSJ3 Homo sapiens Q8IY81 33961781
Intra
H1-2 P16403 BAZ1B Homo sapiens Q9UIG0 33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

H1-2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80158 Histone H1.2 Antibody (YA383) WB, IHC-P, ICC/IF, ChIP, IF-Tissue Human, Mouse, Rat

Related Diseases

Diseases Alias
Supranuclear Palsy, Progressive, 1
  • Progressive Supranuclear Palsy

  • Steele-Richardson-Olszewski Syndrome

  • Supranuclear Palsy, Progressive

  • Progressive Supranuclear Ophthalmoplegia

  • Psp

  • PSNP1

  • Familial Progressive Supranuclear Palsy

  • Richardson'S Syndrome

  • Psp Syndrome

  • Progressive Supranuclear Palsy 1

  • Supranuclear Palsy Progressive

  • Ophthalmoplegia, Supranuclear, Progressive

  • Steele-Richardson-Olszewksi Syndrome

Pick Disease Of Brain
  • Pick Disease

  • Pick'S Disease

  • Pick Disease Of The Brain

  • Lobar Atrophy Of Brain

  • Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

  • Behavioral Variant Of Frontotemporal Dementia

  • Dementia In Pick'S Disease

  • Lobar Atrophy Of The Brain

  • Bvftd

  • Bv-Ftd

  • PIDB

  • Picks Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta H1-2 VGNC VGNC:109667
Rattus norvegicus H1-2 RGD RGD:1587893
Bos taurus H1-2 VGNC VGNC:83558
Mus musculus H1-2 MGD MGI:1931526
Others H1-2 NCBI