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Cat. No.: HY-W1058183

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1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole

1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole is a bromomethyl derivative that inhibits DNA synthesis in tumor cells and promotes the release of radioactivity from labeled nucleic acids. 1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole inhibits the growth of cancer cells in vitro with an ED₅₀ of 2 μg/mL. It can be used in cervical cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 70380-30-2
Formula: C₁₀H₁₀BrN₃
Molecular Weight:252.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole Chemical Structure

CAS No.: 70380-30-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole (compound 6c) potently inhibits the proliferation of HeLa cells in vitro after 72 h, with an ED₅₀ of 2 μg/mL^[1].
1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole can be synthesized via 1,3-dipolar cycloaddition of benzyl azide with propargyl bromide in anhydrous toluene; it can also be prepared by halogenation of 1-benzyl-4-(hydroxymethyl)-1H-1,2,3-triazole using triphenyl phosphite-bromine^[1].
1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole serves as a starting material for the synthesis of 1-benzyl-4-(fluoromethyl)-1H-1,2,3-triazole^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole (compound 6c) does not exhibit significant in vivo cytostatic activity in mice bearing Ehrlich carcinoma ascites tumor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 70380-30-2
Molecular Weight 252.12
Formula C₁₀H₁₀BrN₃
SMILES

BrCC=1N=NN(C1)CC=2C=CC=CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. de las Heras FG, et al. Alkylating nucleosides 1. Synthesis and cytostatic activity of N-glycosyl(halomethyl)-1,2,3-triazoles. A new type of alkylating agent. Journal of medicinal chemistry. 1979 May;22(5):496-501. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole

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1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole

All DNA/RNA Synthesis Isoforms

Biological Activity

Description

In Vitro

In Vivo

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

1-Benzyl-4-(bromomethyl)-1H-1,2,3-triazole Related Classifications

HY-W1058183 Related Classifications

Bioz

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