25,25-Difluoro-27-norcholestenoic acid
25,25-Difluoro-27-norcholestenoic acid is an LXRb ligand that disrupts the His435-Trp457 aromatic-aromatic interaction, destabilizing the H11-H12 region and favoring corepressor binding.
For research use only. We do not sell to patients.
- CAS No.: 2154373-61-0
- Formula: C26H40F2O3
- Molecular Weight:438.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
25,25-Difluoro-27-norcholestenoic acid (18 h) acts as an inverse agonist and antagonist of LXRβ in human HEK293 T cells[1].
25,25-Difluoro-27-norcholestenoic acid (18 h) modulates LXRα activity in human HEK293 T cells[1].
25,25-Difluoro-27-norcholestenoic acid (400 ns) disrupts the His435-Trp457 aromatic-aromatic interaction in LXRβ, inducing conformational changes in the H11-H12 region and destabilizing the agonist arrangement[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2154373-61-0
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Molecular Weight 438.59
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Formula C26H40F2O3
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(F)(F)C(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
25,25-Difluoro-27-norcholestenoic acid Related Classifications
HY-160125 Related Classifications
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