2154373-61-0
2154373-61-0
Chemical Structure
25,25-Difluoro-27-norcholestenoic acid
- CAS No.: 2154373-61-0
- Formula:C26H40F2O3
- Molecular Weight:438.59
IUPAC Name: (R)-2,2-difluoro-6-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)heptanoic acid
InChIKey: ZPGNSRCAPOWIHR-OZECAXSSSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(F)(F)C(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
Biological Activity: 25,25-Difluoro-27-norcholestenoic acid is an LXRb ligand that disrupts the His435-Trp457 aromatic-aromatic interaction, destabilizing the H11-H12 region and favoring corepressor binding[1].
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25,25-Difluoro-27-norcholestenoic acid | 25,25-Difluoro-27-norcholestenoic acid is an LXRb ligand that disrupts the His435-Trp457 aromatic-aromatic interaction, destabilizing the H11-H12 region and favoring corepressor binding. | |||||||||||||||||||||
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