OSBPL7 - oxysterol binding protein like 7 Gene

Also Known as ORP7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114881

About OSBPL7

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,807,372-47,821,794 (from NCBI)

This gene has 11 transcripts (splice variants), 274 orthologues and 11 paralogues. Broad expression in stomach (RPKM 18.4), duodenum (RPKM 12.5) and 22 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

OSBPL7 Products (1)

mRNA Protein Name
NM_145798.3 NP_665741.1 oxysterol-binding protein-related protein 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables cholesterol binding IDA
IDA: Inferred from direct assay
17428193 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21669198 GOA
Biological Process GO Annotation Evidence Références Source
involved in cellular response to cholesterol IMP
IMP: Inferred from mutant phenotype
21669198 GOA
involved in positive regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
21669198 GOA
Cellular Component GO Annotation Evidence Références Source
located in autophagosome IDA
IDA: Inferred from direct assay
21669198 GOA
located in cytosol IDA
IDA: Inferred from direct assay
14593528 GOA
located in perinuclear endoplasmic reticulum IDA
IDA: Inferred from direct assay
14593528 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
14593528 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL7 Protein Structure

PH_8

PH_8: Pleckstrin homology domain (52 - 138)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (478 - 826)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 842 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein-related protein 7

  • ORP-7

Related Diseases

Diseases Alias
Opisthorchiasis

  • Infection By Opisthorchis

  • Infection Due To Opisthorchis

  • Infection Due To Cat Liver Fluke

  • Infection By Cat Liver Fluke

  • Opisthorchiosis

  • Cat Liver Fluke Fever

  • Cat Liver Fluke Disease

  • Opisthorchis Infestation

  • Cat Liver Fluke Infestation
Adult Medulloblastoma

  • Adult Brain Medulloblastoma

  • Medulloblastoma, Adult
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-143200 OSBPL7-IN-1 Inhibitor 99.84% Unkown
HY-RS09844 OSBPL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21167 Osbpl7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27684 Osbpl7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta OSBPL7 VGNC VGNC:75626
Rattus norvegicus OSBPL7 RGD RGD:1309141
Bos taurus OSBPL7 VGNC VGNC:32465
Felis catus OSBPL7 VGNC VGNC:63982
Mus musculus OSBPL7 MGD MGI:1918490
Canis familiaris OSBPL7 VGNC VGNC:44157
Others OSBPL7 NCBI