FCRL1 - Fc receptor like 1 Gene

Also Known as FCRH1; IFGP1; IRTA5; CD307a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115350

About FCRL1

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,794,403-157,820,120 (from NCBI)

This gene has 8 transcripts (splice variants), 86 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 18.4), spleen (RPKM 14.4) and 3 other tissues.

Summary

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of Cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

FCRL1 Products (3)

mRNA Protein Name
NM_001159397.2 NP_001152869.1 Fc receptor-like protein 1 isoform 2 precursor
NM_001159398.2 NP_001152870.1 Fc receptor-like protein 1 isoform 3 precursor
NM_052938.5 NP_443170.1 Fc receptor-like protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
15479727 GOA
Biological Process GO Annotation Evidence Références Source
involved in B cell activation IDA
IDA: Inferred from direct assay
15479727 GOA
Cellular Component GO Annotation Evidence Références Source
located in cell surface IDA
IDA: Inferred from direct assay
16849395 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCRL1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (19 - 93)

Ig_2

Ig_2: Immunoglobulin domain (118 - 201)

Ig_3

Ig_3: Immunoglobulin domain (210 - 280)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
Protein Preferred Names Protein Names

Fc receptor-like protein 1

  • IFGP family protein 1

Recombinant FCRL1 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P72655 FCRL1 Protein, Human (HEK293, His) Q96LA6-1 (A17-N303) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04842 FCRL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04848 FCRLA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18816 Fcrl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20925 Fcrla Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25306 Fcrl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FCRL1 VGNC VGNC:103646
Macaca mulatta FCRL1 VGNC VGNC:72528
Felis catus FCRL1 VGNC VGNC:82477
Rattus norvegicus FCRL1 RGD RGD:1589411
Bos taurus FCRL1 VGNC VGNC:50049
Mus musculus FCRL1 MGD MGI:2442862
Others FCRL1 NCBI