GRIN3B - glutamate ionotropic receptor NMDA type subunit 3B Gene

Also Known as NR3B; GluN3B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116444

About GRIN3B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,000,419-1,009,732 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 17 paralogues. Ubiquitous expression in spleen (RPKM 1.5), fat (RPKM 1.0) and 21 other tissues.

Summary

The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]

GRIN3B Products (1)

mRNA Protein Name
NM_138690.3 NP_619635.1 glutamate receptor ionotropic, NMDA 3B precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
22564863 GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
22564863 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIN3B Protein Structure

SBP_bac_3

SBP_bac_3: Bacterial extracellular solute-binding proteins, family 3 (478 - 809)

Lig_chan

Lig_chan: Ligand-gated ion channel (575 - 842)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1043 a.a.
Protein Preferred Names Protein Names

glutamate receptor ionotropic, NMDA 3B

  • N-methyl-D-aspartate receptor subtype 3B

Related Diseases

Diseases Alias
Depersonalization Disorder

  • Neurotic Derealization

  • Depersonalization

  • Depersonalization/Derealization Disorder

  • Depersonalisation-Derealization Syndrome

  • Depersonalisation Disorder

  • Depersonalisation Neurosis

  • Depersonalisation Syndrome

  • Feeling Of Unreality

  • Feels Own Self Is Unreal

  • Neurotic State With Depersonalisation

  • Neurotic State With Depersonalization Episode
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Dissociative Disorder

  • Dissociative Disorders

  • Dissociative Disease

  • Dissociative Reaction
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
West Syndrome

  • Infantile Spasms

  • Infantile Spasms Syndrome

  • Infantile Spasm

  • X-Linked Infantile Spasm Syndrome

  • X-Linked Infantile Spasms

  • Epileptic Encephalopathy, Early Infantile, 1

  • Is

  • Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg

  • West'S Syndrome

  • Spasms, Infantile

  • Is -[Infantile Spasm]

  • Salaam Spasm

  • Salaam Tic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05807 GRIN3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GRIN3B RGD RGD:621705
Felis catus GRIN3B VGNC VGNC:80056
Bos taurus GRIN3B VGNC VGNC:55211
Mus musculus GRIN3B MGD MGI:2150393
Others GRIN3B NCBI