PIGU - phosphatidylinositol glycan anchor biosynthesis class U Gene

Also Known as GAB1; PIG-U; NEDBSS; CDC91L1; GPIBD21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 128869

About PIGU

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,560,542-34,677,092 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 6.6), ovary (RPKM 5.2) and 25 other tissues.

Summary

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]

PIGU Products (1)

mRNA Protein Name
NM_080476.5 NP_536724.1 phosphatidylinositol glycan anchor biosynthesis class U protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
contributes to GPI anchor binding IMP
IMP: Inferred from mutant phenotype
12802054 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in GPI anchor biosynthetic process IDA
IDA: Inferred from direct assay
15034568 GOA
involved in attachment of GPI anchor to protein IMP
IMP: Inferred from mutant phenotype
12802054 GOA
involved in regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
15034568 GOA
Cellular Component GO Annotation Evidence Références Source
part of GPI-anchor transamidase complex IDA
IDA: Inferred from direct assay
12802054 GOA
part of GPI-anchor transamidase complex IPI
IPI: Inferred from physical interaction
12802054 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15034568 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIGU Protein Structure

PIG-U

PIG-U: GPI transamidase subunit PIG-U (11 - 394)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 435 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol glycan anchor biosynthesis class U protein

  • CDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1

PIGU Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PIGU Q9H490 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
PIGU Q9H490 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Brain Anomalies, Seizures, And Scoliosis

  • Glycosylphosphatidylinositol Biosynthesis Defect 21

  • NEDBSS

  • Gpibd21
Developmental And Epileptic Encephalopathy 80

  • DEE80

  • Glycosylphosphatidylinositol Biosynthesis Defect 20

  • Gpibd20

  • Epileptic Encephalopathy, Early Infantile, 80

  • Eiee80

  • Developmental And Epileptic Encephalopathy, 80

  • Early Infantile Epileptic Encephalopathy 80
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS10503 PIGU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14921 TP53INP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PIGU VGNC VGNC:64169
Bos taurus PIGU VGNC VGNC:32879
Mus musculus PIGU MGD MGI:3039607
Rattus norvegicus PIGU RGD RGD:727825
Canis familiaris PIGU VGNC VGNC:44543
Macaca mulatta PIGU VGNC VGNC:107915
Others PIGU NCBI