Drd3 - dopamine receptor D3 Gene

Also Known as D3R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13490

About Drd3

Chromosome 16: 43,574,389-43,643,295 forward strand.GRCm39:CM001009.3

This gene has 2 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 39 phenotypes. Low expression observed in reference dataset.

Summary

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including regulation of blood pressure; regulation of Dopamine Receptor signaling pathway; and response to alkaloid. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (Dopamine Receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

Drd3 Products (1)

mRNA Protein Name
NM_007877.2 NP_031903.1 D(3) dopamine receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
IDA: Inferred from direct assay
7566118 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16386234 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of G protein-coupled dopamine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
12097513 MGI
acts upstream of G protein-coupled dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15016423 MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
16386234 MGI
involved in behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
10432116 MGI
acts upstream of or within circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
15878801 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
9354330 MGI
NOT acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
10221759 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
8700864 MGI
acts upstream of or within musculoskeletal movement, spinal reflex action IMP
IMP: Inferred from mutant phenotype
15601940 MGI
acts upstream of or within negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
9691085 MGI
acts upstream of or within negative regulation of dopamine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
12097513 MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation IDA
IDA: Inferred from direct assay
9651217 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
17251429 MGI
acts upstream of oligodendrocyte differentiation IDA
IDA: Inferred from direct assay
9651217 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
17251429 MGI
acts upstream of or within positive regulation of dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15016423 MGI
acts upstream of or within regulation of blood volume by renin-angiotensin IGI
IGI: Inferred from genetic interaction
9691085 MGI
acts upstream of or within regulation of blood volume by renin-angiotensin IMP
IMP: Inferred from mutant phenotype
9691085 MGI
acts upstream of or within regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
9482807 MGI
acts upstream of or within regulation of lipid metabolic process IMP
IMP: Inferred from mutant phenotype
15084447 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
15084447 MGI
involved in regulation of neurotransmitter uptake EXP
EXP: Inferred from Experiment
27393374 MGI
involved in regulation of neurotransmitter uptake IDA
IDA: Inferred from direct assay
27393374 MGI
acts upstream of or within response to amphetamine IGI
IGI: Inferred from genetic interaction
12097513 MGI
acts upstream of or within response to cocaine IMP
IMP: Inferred from mutant phenotype
10943692 MGI
NOT acts upstream of or within response to ethanol IMP
IMP: Inferred from mutant phenotype
12873629 MGI
acts upstream of or within response to ethanol IMP
IMP: Inferred from mutant phenotype
11988344 MGI
acts upstream of or within response to morphine IMP
IMP: Inferred from mutant phenotype
12574430 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
12097513 MGI
Cellular Component GO Annotation Evidence Références Source
is active in dopaminergic synapse EXP
EXP: Inferred from Experiment
27393374 MGI
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
27393374 MGI
located in membrane IDA
IDA: Inferred from direct assay
9651217 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9651217 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd3 Protein Structure

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (29 - 439)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (30 - 56)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (63 - 86)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (102 - 132)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (149 - 167)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (184 - 209)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (367 - 397)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (407 - 432)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
Protein Preferred Names Protein Names

D(3) dopamine receptor

  • dopamine D3 receptor

  • dopamine receptor 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-19654 GSK598809 Antagonist 99.73% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-19654C (-)-GSK598809 hydrochloride Antagonist 98.66% Unkown
HY-19654B (-)-GSK598809 Antagonist / Unkown
HY-RS04000 DRD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04001 Drd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04002 Drd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Drd3 NCBI NCBI:1814