F2rl3 - coagulation factor II (thrombin) receptor-like 3 Gene

Also Known as PAR4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14065

About F2rl3

Chromosome 8: 73,488,508-73,490,502 forward strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 194 orthologues, 16 paralogues and is associated with 2 phenotypes. Broad expression in spleen adult (RPKM 9.1), thymus adult (RPKM 4.3) and 2 other tissues.

Summary

This gene encodes a member of the Protease-activated Receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Mice lacking a functional copy of this gene exhibit impaired platelet activation and prolonged bleeding times. [provided by RefSeq, Sep 2016]

F2rl3 Products (1)

mRNA Protein Name
NM_007975.4 NP_032001.2 proteinase-activated receptor 4 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Références Source
acts upstream of or within platelet aggregation IDA
IDA: Inferred from direct assay
28032533 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2rl3 Protein Structure

7tmA_PAR4

7tmA_PAR4: cd15372 (89 - 362)

7tmA_PAR4

7tmA_PAR4: cd15372 (89 - 116)

7tmA_PAR4

7tmA_PAR4: cd15372 (122 - 147)

7tmA_PAR4

7tmA_PAR4: cd15372 (160 - 190)

7tmA_PAR4

7tmA_PAR4: cd15372 (202 - 224)

7tmA_PAR4

7tmA_PAR4: cd15372 (252 - 281)

7tmA_PAR4

7tmA_PAR4: cd15372 (287 - 317)

7tmA_PAR4

7tmA_PAR4: cd15372 (330 - 355)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
Protein Preferred Names Protein Names

proteinase-activated receptor 4

  • PAR-4

  • coagulation factor II receptor-like 3

  • thrombin receptor-like 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04640 F2RL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04641 F2rl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04642 F2rl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F2rl3 NCBI NCBI:9002