Gnao1 - guanine nucleotide binding protein, alpha O Gene

Also Known as Gnao; Hg1g; alphaO; Galphao

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14681

Summary

Enables GTP binding activity and GTPase activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; Dopamine Receptor signaling pathway; and locomotory behavior. Located in cell body and dendrite. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Used to study developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Apr 2022]

Gnao1 Products (2)

mRNA	Protein	Name
NM_001113384.1	NP_001106855.1	guanine nucleotide-binding protein G(o) subunit alpha isoform B
NM_010308.3	NP_034438.1	guanine nucleotide-binding protein G(o) subunit alpha isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables G protein activity	IDA IDA: Inferred from direct assay	10926822	MGI
enables GTP binding	IMP IMP: Inferred from mutant phenotype	11248120	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10926822	MGI

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within G protein-coupled dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11248120	MGI
acts upstream of or within G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9501252	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	9501252	MGI
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	20622165	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	33535037	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	33535037	MGI
acts upstream of or within regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	9050846	MGI
acts upstream of negative effect vesicle docking involved in exocytosis	IMP IMP: Inferred from mutant phenotype	20622165	MGI

Cellular Component GO Annotation	Evidence	Références	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	34248508	MGI
located in cell body	IDA IDA: Inferred from direct assay	11685543	MGI
located in dendrite	IDA IDA: Inferred from direct assay	11685543	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34248508	MGI
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	34248508	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	34248508	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	34248508	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein G(o) subunit alpha	GTP-binding protein alpha-o subunit Go alpha heterotrimeric guanine nucleotide-binding protein 1g

Recombinant Gnao1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P72207	GNAO1 Protein, Mouse (His)	P18872 (G2-Y354)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS05538	GNAO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18822	Gnao1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25312	Gnao1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnao1	NCBI	NCBI:2775