KIF18B - kinesin family member 18B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 146909

About KIF18B

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,924,711-44,947,773 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and 41 paralogues. Broad expression in bone marrow (RPKM 3.6), lymph node (RPKM 2.4) and 14 other tissues.

Summary

Enables cytoskeletal motor activity and Kinesin binding activity. Involved in microtubule depolymerization; mitotic cell cycle; and regulation of cell division. Located in cytosol; microtubule; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

KIF18B Products (2)

mRNA Protein Name
NM_001264573.2 NP_001251503.1 kinesin-like protein KIF18B isoform 2
NM_001265577.2 NP_001252506.1 kinesin-like protein KIF18B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables cytoskeletal motor activity IDA
IDA: Inferred from direct assay
21820309 GOA
enables kinesin binding IPI
IPI: Inferred from physical interaction
21820309 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21820309 GOA
Biological Process GO Annotation Evidence Références Source
involved in microtubule depolymerization IDA
IDA: Inferred from direct assay
21820309 GOA
involved in mitotic cell cycle IDA
IDA: Inferred from direct assay
20600703 GOA
involved in regulation of cell division IDA
IDA: Inferred from direct assay
20600703 GOA
Cellular Component GO Annotation Evidence Références Source
located in astral microtubule IDA
IDA: Inferred from direct assay
21820309 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20600703 GOA
located in microtubule plus-end IDA
IDA: Inferred from direct assay
21820309 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20600703 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF18B Protein Structure

Kinesin

Kinesin: Kinesin motor domain (13 - 351)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 852 a.a.
Protein Preferred Names Protein Names

kinesin-like protein KIF18B

Related Diseases

Diseases Alias
Filippi Syndrome

  • Scott Craniodigital Syndrome With Mental Retardation

  • Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome

  • FLPIS

  • Scott Bryant Graham Syndrome

  • Craniodigital-Intellectual Disability Syndrome

  • Scott Craniodigital Syndrome

  • Scott-Bryant-Graham Syndrome

  • Syndactyly, Type I, With Microcephaly And Mental Retardation

  • Syndactyly Type I With Microcephaly And Intellectual Disability

  • Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly

  • Craniodigital Syndrome With Intellectual Disability

  • Craniodigital Syndrome-Intellectual Disability Syndrome

  • Craniodigital Syndrome-Intellectual Disability, Scott Type

  • Intellectual Disability-Craniodigital Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS07268 KIF18B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KIF18B RGD RGD:1310360
Canis familiaris KIF18B VGNC VGNC:42388
Bos taurus KIF18B VGNC VGNC:30588
Mus musculus KIF18B MGD MGI:2446979
Felis catus KIF18B VGNC VGNC:63108
Macaca mulatta KIF18B VGNC VGNC:99162
Others KIF18B NCBI