IRX2 - iroquois homeobox 2 Gene

Also Known as IRXA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 153572

About IRX2

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:2,735,635-2,751,677 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in lung (RPKM 4.6), skin (RPKM 2.8) and 9 other tissues.

Summary

IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

IRX2 Products (2)

mRNA Protein Name
NM_001134222.2 NP_001127694.1 iroquois-class homeodomain protein IRX-2
NM_033267.5 NP_150366.1 iroquois-class homeodomain protein IRX-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
26560478 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
26560478 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRX2 Protein Structure

Homeobox_KN

Homeobox_KN: Homeobox KN domain (132 - 171)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
Protein Preferred Names Protein Names

iroquois-class homeodomain protein IRX-2

  • homeodomain protein IRXA2

IRX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
IRX2 Q9BZI1 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
IRX2 Q9BZI1 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
IRX2 Q9BZI1 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
Intra
IRX2 Q9BZI1 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
Intra
IRX2 Q9BZI1 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
Intra
IRX2 Q9BZI1 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
IRX2 Q9BZI1 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Kidney Clear Cell Sarcoma

  • Clear Cell Sarcoma Of Kidney

  • Childhood Kidney Clear Cell Sarcoma

  • Renal Clear Cell Sarcoma

  • Ccsk

  • Clear Cell Sarcoma Of The Kidney
Pilocytic Astrocytoma Of Cerebellum

  • Cerebellar Pilocytic Astrocytoma
Anthracosis

  • Black Lung

  • Coal Workers' Pneumoconiosis

  • Melanoedema

  • Black Lung Disease

  • Pneumoconiosis

  • Coal Miner'S Pneumoconiosis

  • Coal Workers' Lung

  • Coal Worker'S Pneumoconiosis

  • Coal Workers Pneumoconiosis

  • Coal Miners' Lung

  • Coal Miners' Pneumoconiosis

  • Coal Pneumoconiosis

  • Colliers' Anthracosis

  • Colliers' Lung

  • Lung Melanosis

  • Miners' Asthma

  • Miners' Lung

  • Pneumomelanosis

  • Cwp - [Coalworkers Pneumoconiosis]

  • Fibrosis Of Lung With Anthracosilicosis

  • Lung Fibrosis With Anthracosis

  • Miners' Pneumoconiosis

  • Carbon Lung

  • Coalworker Lung

  • Collier'S Asthma

  • Anthracosilicosis

  • Lung Anthracosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06921 IRX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IRX2 MGD MGI:1197526
Canis familiaris IRX2 VGNC VGNC:42101
Bos taurus IRX2 VGNC VGNC:54439
Rattus norvegicus IRX2 RGD RGD:1309834
Macaca mulatta IRX2 VGNC VGNC:73592
Felis catus IRX2 VGNC VGNC:102236
Others IRX2 NCBI