Ruvbl2 - RuvB-like protein 2 Gene

Also Known as p47; mp47

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20174

Summary

Enables several functions, including ATPase binding activity; TFIID-class transcription factor complex binding activity; and adenyl ribonucleotide binding activity. Predicted to be involved in several processes, including box C/D snoRNP assembly; histone acetylation; and positive regulation of nitrogen compound metabolic process. Predicted to act upstream of or within DNA recombination; DNA repair; and chromatin organization. Part of ribonucleoprotein complex. Is expressed in several structures, including axial musculature; branchial arch; limb; sensory organ; and viscerocranium. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ruvbl2 Products (1)

mRNA Protein Name
NM_011304.4 NP_035434.1 ruvB-like 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables ADP binding IDA
IDA: Inferred from direct assay
17636026 MGI
enables ATP binding IDA
IDA: Inferred from direct assay
17636026 MGI
enables ATPase binding IPI
IPI: Inferred from physical interaction
17636026 MGI
enables TFIID-class transcription factor complex binding IPI
IPI: Inferred from physical interaction
17636026 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17636026 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
17636026 MGI
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of DNA repair IDA
IDA: Inferred from direct assay
23979016 MGI
involved in positive regulation of telomere maintenance in response to DNA damage IMP
IMP: Inferred from mutant phenotype
23979016 MGI
involved in regulation of DNA repair IDA
IDA: Inferred from direct assay
23979016 MGI
involved in regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
23979016 MGI
involved in telomere maintenance IMP
IMP: Inferred from mutant phenotype
23979016 MGI
Cellular Component GO Annotation Evidence Références Source
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
19299493 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ruvB-like 2

  • reptin

Ruvbl2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Ruvbl2 Q9WTM5 Ruvbl1 Mus musculus P60122
Y2H Array
20211142
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-146074 RUVBL1/2 ATPase-IN-1 Inhibitor 99.63% Unkown
HY-103702 TIP48/49-IN-1 99.07% Unkown
HY-RS12355 RUVBL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17670 Ruvbl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24131 Ruvbl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ruvbl2 NCBI NCBI:10856