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RUVBL2 - RuvB like AAA ATPase 2 Gene

Also Known as RVB2; TIH2; ECP51; TIP48; CGI-46; ECP-51; INO80J; REPTIN; TIP49B; TAP54-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10856

About RUVBL2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,993,448-49,015,995 (from NCBI)

This gene has 14 transcripts (splice variants), 196 orthologues and 1 paralogue. Broad expression in testis (RPKM 64.1), colon (RPKM 12.0) and 24 other tissues.

Summary

This gene encodes the second human homologue of the Bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

RUVBL2 Products (3)

mRNA	Protein	Name
NM_001321190.2	NP_001308119.1	ruvB-like 2 isoform 2
NM_001321191.1	NP_001308120.1	ruvB-like 2 isoform 3
NM_006666.3	NP_006657.1	ruvB-like 2 isoform 1

RUVBL2 Protein Structure

TIP49

0
100
200
300
400
463 a.a.

Protein Preferred Names	Protein Names
ruvB-like 2	48 kDa TATA box-binding protein-interacting protein

RUVBL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RUVBL2	Q9Y230	CCDC103	Homo sapiens	Q8IW40	Validated Y2H	25416956
Intra	RUVBL2	Q9Y230	CCDC103	Homo sapiens	Q8IW40	Y2H Array	25416956
Cross	RUVBL2	Q9Y230	Dpcd	Mus musculus	Q8BPA8	Anti Tag CoIP	29959317
Intra	RUVBL2	Q9Y230	RUVBL1	Homo sapiens	Q9Y265	Anti Tag CoIP	10966108
Intra	RUVBL2	Q9Y230	RUVBL1	Homo sapiens	Q9Y265	Anti Bait CoIP	16230350
Intra	RUVBL2	Q9Y230	DNAJB4	Homo sapiens	Q9UDY4	Y2H Array	32296183
Intra	RUVBL2	Q9Y230	DNAJB4	Homo sapiens	Q9UDY4	Y2H Prey Pooling	32296183
Intra	RUVBL2	Q9Y230	EP400	Homo sapiens	Q96L91	Anti Tag CoIP	28514442
Intra	RUVBL2	Q9Y230	EP400	Homo sapiens	Q96L91	Anti Tag CoIP	35271311
Intra	RUVBL2	Q9Y230	EP400	Homo sapiens	Q96L91	Anti Tag CoIP	33961781
Intra	RUVBL2	Q9Y230	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	RUVBL2	Q9Y230	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	RUVBL2	Q9Y230	DPCD	Homo sapiens	Q9BVM2	Y2H Pooling	16189514
Intra	RUVBL2	Q9Y230	DPCD	Homo sapiens	Q9BVM2	Anti Bait CoIP	17353931
Intra	RUVBL2	Q9Y230	DPCD	Homo sapiens	Q9BVM2	Y2H Prey Pooling	25416956
Intra	RUVBL2	Q9Y230	DPCD	Homo sapiens	Q9BVM2	Anti Tag CoIP	33961781
Intra	RUVBL2	Q9Y230	DPCD	Homo sapiens	Q9BVM2	Anti Tag CoIP	28514442
Intra	RUVBL2	Q9Y230	DPCD	Homo sapiens	Q9BVM2	Y2H Array	25416956
Intra	RUVBL2	Q9Y230	DPCD	Homo sapiens	Q9BVM2	Anti Tag CoIP	35271311
Intra	RUVBL2	Q9Y230	YY1	Homo sapiens	P25490	Anti Tag CoIP	28514442
Intra	RUVBL2	Q9Y230	YY1	Homo sapiens	P25490	Pull Down	18026119
Intra	RUVBL2	Q9Y230	YY1	Homo sapiens	P25490	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RUVBL2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71661	RUVBL2 Protein, Human (His-SUMO)	Q9Y230-1 (A2-S463)	≥ 90%, as determined by reducing SDS-PAGE.

RUVBL2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83603	Reptin Antibody (YA3348)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Hemangioma Of Spleen	Splenic Hemangioma
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1	Smard1 DSMA1 Sianrf Dhmn6 Spinal Muscular Atrophy With Respiratory Distress 1 HMN6 Severe Infantile Axonal Neuropathy With Respiratory Failure Autosomal Recessive Distal Spinal Muscular Atrophy 1 Diaphragmatic Spinal Muscular Atrophy Spinal Muscular Atrophy With Respiratory Distress Type 1 Neuronopathy, Distal Hereditary Motor, Type Vi Hmn Vi Neuronopathy, Severe Infantile Axonal, With Respiratory Failure Distal Spinal Muscular Atrophy 1 Autosomal Recessive Spinal Muscular Atrophy With Respiratory Distress Distal Hereditary Motor Neuropathy Type 6 Distal-Hmn Type 6 Severe Infantile Axonal Neuropathy With Respiratory Failure Type 1 Spinal Muscular Atrophy, Diaphragmatic Distal Hereditary Motor Neuronopathy Type Vi Distal Spinal Muscular Atrophy Type 1 Hmnvi Spinal Muscular Atrophy With Respiratory Distress Autosomal Recessive Distal Spinal Muscular Atrophy Type 1 Neuronopathy, Distal Hereditary Motor, 6 Dhmn Vi Distal Hereditary Motor Neuropathy Type Vi Severe Infantile Axonal Neuronopathy With Respiratory Failure Spinal Muscular Atrophy Distal Autosomal Recessive 1 Atrophy, Muscular, Spinal, Distal, Type 1
Autosomal Recessive Distal Hereditary Motor Neuronopathy	Autosomal Recessive Distal Spinal Muscular Atrophy
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-146074	RUVBL1/2 ATPase-IN-1	Inhibitor	99.63%	Unkown
HY-103702	TIP48/49-IN-1		99.07%	Unkown
HY-RS12355	RUVBL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17670	Ruvbl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24131	Ruvbl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RUVBL2	VGNC	VGNC:34224
Macaca mulatta	RUVBL2	VGNC	VGNC:76950
Mus musculus	RUVBL2	MGD	MGI:1342299
Canis familiaris	RUVBL2	VGNC	VGNC:45812
Felis catus	RUVBL2	VGNC	VGNC:64826
Rattus norvegicus	RUVBL2	RGD	RGD:1306509
Others	RUVBL2	NCBI