DPCD - deleted in primary ciliary dyskinesia homolog (mouse) Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25911

About DPCD

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,588,321-101,609,662 (from NCBI)

This gene has 6 transcripts (splice variants) and 202 orthologues. Broad expression in testis (RPKM 51.1), kidney (RPKM 13.2) and 19 other tissues.

Summary

This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]

DPCD Products (6)

mRNA Protein Name
NM_001329742.2 NP_001316671.1 protein DPCD isoform 1
NM_001329743.2 NP_001316672.1 protein DPCD isoform 3
NM_001329744.2 NP_001316673.1 protein DPCD isoform 4
NM_001329745.2 NP_001316674.1 protein DPCD isoform 5
NM_001329746.2 NP_001316675.1 protein DPCD isoform 6
NM_015448.3 NP_056263.1 protein DPCD isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPCD Protein Structure

DPCD

DPCD: DPCD protein family (6 - 197)

  • 0
  • 100
  • 203 a.a.
Protein Preferred Names Protein Names

protein DPCD

  • RP11-529I10.4

DPCD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DPCD Q9BVM2 RUVBL2 Homo sapiens Q9Y230
Validated Y2H
32296183
Intra
DPCD Q9BVM2 RUVBL2 Homo sapiens Q9Y230
Validated Y2H
25416956
Intra
DPCD Q9BVM2 RUVBL2 Homo sapiens Q9Y230
Y2H Prey Pooling
32296183
Intra
DPCD Q9BVM2 RUVBL2 Homo sapiens Q9Y230
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pulmonary Subvalvular Stenosis

  • Pulmonary Infundibular Stenosis

  • Congenital Infundibular Stenosis

  • Infundibular Pulmonic Stenosis

  • Infundibular Pulmonic Stenosis, Congenital

  • Subvalvular Pulmonic Stenosis
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Intellectual Developmental Disorder, Autosomal Dominant 29

  • MRD29

  • Autosomal Dominant Non-Syndromic Intellectual Disability 29

  • Mental Retardation, Autosomal Dominant 29

  • Autosomal Dominant Intellectual Developmental Disorder 29

  • Autosomal Dominant Mental Retardation 29

  • Mental Retardation, Autosomal Dominant, Type 29
Brachydactyly, Type A2

  • Brachydactyly Type A2

  • BDA2

  • Mohr-Wriedt Type Brachydactyly

  • Brachymesophalangy Ii

  • Brachymesophalangy Type 2

  • Brachymesophalangy 2

  • Brachydactyly, Mohr-Wriedt Type

  • Brachydactyly A2
Intellectual Developmental Disorder, Autosomal Dominant 5

  • MRD5

  • Autosomal Dominant Non-Syndromic Intellectual Disability 5

  • Intellectual Disability, Autosomal Dominant 5

  • Mental Retardation, Autosomal Dominant 5

  • Autosomal Dominant Intellectual Developmental Disorder 5

  • Syngap1-Related Non-Syndromic Intellectual Disability

  • Autosomal Dominant Intellectual Disability 5

  • Syngap1 Syndrome

  • Syngap1-Related Nsid

  • Syngap1 Gene Mutation Linked To Intellectual Disability, Schizophrenia And Autism
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

  • Polycystic Kidney Disease 1

  • PKD1

  • Adpkd

  • Polycystic Kidney Disease, Adult, Type I

  • Apkd1

  • Potter Type Iii Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult

  • Potter Type Iii Polycystic Kidney Disease, Formerly

  • Polycystic Kidney Disease, Type 1

  • Adpkd1

  • Adult Polycystic Kidney Disease Type 1

  • Autosomal Dominant Polycystic Kidney Disease 1

  • Pkd-1

  • Polycystic Kidney Disease Adult

  • Polycystic Kidney Disease Type I

  • Polycystic Kidneys

  • Polycystic Kidney Disease, Adult Type I

  • Polycystic Kidney Type 1 Autosomal Dominant Disease

  • Kidney Disease, Polycystic, Type 1

  • Polycystic Kidney, Autosomal Dominant

  • Polycystic Kidney, Type 1 Autosomal Dominant Disease

  • Polycystic Kidney Diseases
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03946 DPCD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DPCD MGD MGI:1924407
Rattus norvegicus DPCD RGD RGD:1307648
Macaca mulatta DPCD VGNC VGNC:106036
Canis familiaris DPCD VGNC VGNC:56112
Bos taurus DPCD VGNC VGNC:55947
Others DPCD NCBI