NAV3 - neuron navigator 3 Gene

Also Known as POMFIL1; unc53H3; STEERIN3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89795

About NAV3

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:77,571,862-78,213,010 (from NCBI)

This gene has 16 transcripts (splice variants), 215 orthologues and 2 paralogues. Broad expression in brain (RPKM 3.5), ovary (RPKM 2.8) and 14 other tissues.

Summary

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]

NAV3 Products (2)

mRNA Protein Name
NM_001024383.2 NP_001019554.1 neuron navigator 3 isoform 1
NM_014903.6 NP_055718.4 neuron navigator 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables microtubule binding IDA
IDA: Inferred from direct assay
25678558 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
25678558 GOA
involved in negative regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
16166283 GOA
involved in negative regulation of microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
25678558 GOA
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
25678558 GOA
Cellular Component GO Annotation Evidence Références Source
colocalizes with microtubule end IMP
IMP: Inferred from mutant phenotype
25678558 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAV3 Protein Structure

CH

CH: Calponin homology (CH) domain (83 - 182)

AAA_14

AAA_14: AAA domain (2051 - 2162)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2385 a.a.
Protein Preferred Names Protein Names

neuron navigator 3

  • pore membrane and/or filament interacting like protein 1

Related Diseases

Diseases Alias
Panniculitis

  • Nodular Panniculitis
Sucrase-Isomaltase Deficiency, Congenital

  • Congenital Sucrase-Isomaltase Deficiency

  • CSID

  • Si Deficiency

  • Congenital Sucrose Intolerance

  • Disaccharide Intolerance

  • Sucrase-Isomaltase Deficiency

  • Disaccharide Intolerance I

  • Congenital Sucrose-Isomaltose Malabsorption

  • Sucrose-Isomaltose Malabsorption, Congenital

  • Sucrose Intolerance, Congenital

  • Congenital Sucrase-Isomaltose Malabsorption

  • Congenital Sucrose-Isomaltase Malabsorption

  • Disaccharide Intolerance, 1

  • Sucrose Intolerance Congenital

  • Sucrose-Isomaltase Malabsorption, Congenital

  • Disaccharidase Deficiency

  • Invertase Deficiency

  • Sucrase-Alpha-Dextrinase Deficiency

  • Disaccharide Intolerance Type I

  • Csid - [Congenital Sucrase-Isomaltase Deficiency]

  • Sucrose Intolerance Of Newborn

  • Sucrose Intolerance

  • Sucrase Deficiency

  • Disaccharide Malabsorption

  • Intestinal Disaccharidase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09048 NAV3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NAV3 VGNC VGNC:43631
Mus musculus NAV3 MGD MGI:2183703
Macaca mulatta NAV3 VGNC VGNC:74969
Rattus norvegicus NAV3 RGD RGD:1306259
Felis catus NAV3 VGNC VGNC:63728
Bos taurus NAV3 VGNC VGNC:31892
Others NAV3 NCBI