MLEC - malectin Gene

Also Known as KIAA0152

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9761

About MLEC

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,687,149-120,701,859 (from NCBI)

This gene has 5 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in colon (RPKM 16.3), thyroid (RPKM 15.6) and 25 other tissues.

Summary

This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

MLEC Products (3)

mRNA Protein Name
NM_001303627.2 NP_001290556.1 malectin isoform 2
NM_001303628.2 NP_001290557.1 malectin isoform 3 precursor
NM_014730.4 NP_055545.1 malectin isoform1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
22988243 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30021884 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
31831667 GOA
Cellular Component GO Annotation Evidence Références Source
part of oligosaccharyltransferase complex IPI
IPI: Inferred from physical interaction
31831667 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLEC Protein Structure

Malectin

Malectin: Di-glucose binding within endoplasmic reticulum (48 - 208)

  • 0
  • 100
  • 200
  • 292 a.a.
Protein Preferred Names Protein Names

malectin

  • oligosaccharyltransferase complex subunit (non-catalytic)

MLEC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MLEC Q14165 RPN1 Homo sapiens P04843
GMS
31831667
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Advanced Sleep Phase Syndrome, Familial, 1

  • Advanced Sleep Phase Syndrome 1

  • FASPS1

  • Familial Advanced Sleep Phase Syndrome 1

  • Sleep Phase Syndrome, Advanced, Familial, Type 1
Congenital Disorder Of Glycosylation, Type Iib

  • CDG2B

  • CDGIIB

  • Glucosidase I Deficiency

  • Congenital Disorder Of Glycosylation Type Iib

  • Cdg Iib

  • Mogs-Cdg

  • Cdg Syndrome Type Iib

  • Cdg-Iib

  • Carbohydrate Deficient Glycoprotein Syndrome Type Iib

  • Congenital Disorder Of Glycosylation Type 2b

  • Glucosidase 1 Deficiency

  • Type Iib Congenital Disorder Of Glycosylation

  • Glycosylation, Congenital Disorder Of, Type Iib
Newfoundland Rod-Cone Dystrophy

  • Newfoundland Cone-Rod Dystrophy

  • NFRCD

  • Rod-Cone Dystrophy Newfoundland
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Autosomal Recessive Intellectual Developmental Disorder

  • Mental Retardation, Autosomal Recessive

  • Autosomal Recessive Mental Retardation

  • Autosomal Recessive Non-Syndromic Mental Retardation

  • Autosomal Recessive Non-Syndromic Intellectual Disability
Congenital Disorder Of Glycosylation, Type In

  • Congenital Disorder Of Glycosylation

  • CDG1N

  • Congenital Disorders Of Glycosylation

  • Cdg In

  • Cdgin

  • Congenital Disorder Of Glycosylation 1n

  • Carbohydrate-Deficient Glycoprotein Syndrome

  • Cdg

  • Rft1-Cdg

  • Cdg-In

  • Congenital Disorder Of Glycosylation Type In

  • Carbohydrate Deficient Glycoprotein Syndrome

  • Cdg Syndrome

  • Congenital Disorder Of Glycosylation In

  • Carbohydrate-Deficient Glycoprotein Syndromes

  • Cdg Syndrome Type In

  • Carbohydrate Deficient Glycoprotein Syndrome Type In

  • Congenital Disorder Of Glycosylation Type 1n

  • Man5glcnac2-Pp-Dol Flippase Deficiency

  • Glycosylation, Congenital Disorder Of

  • Glycosylation, Congenital Disorder Of, Type In
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08486 MLEC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MLEC VGNC VGNC:74851
Mus musculus MLEC MGD MGI:1924015
Canis familiaris MLEC VGNC VGNC:43256
Rattus norvegicus MLEC RGD RGD:1307736
Bos taurus MLEC VGNC VGNC:31496
Felis catus MLEC VGNC VGNC:63522
Others MLEC NCBI