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RPN1 - ribophorin I Gene

Also Known as OST1; RBPH1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6184

About RPN1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:128,619,969-128,650,818 (from NCBI)

This gene has 8 transcripts (splice variants), 213 orthologues and is associated with 63 phenotypes. Ubiquitous expression in thyroid (RPKM 116.8), placenta (RPKM 79.5) and 25 other tissues.

Summary

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S Proteasome and may mediate binding of ubiquitin-like domains to this Proteasome. [provided by RefSeq, Jul 2008]

RPN1 Products (1)

mRNA	Protein	Name
NM_002950.4	NP_002941.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19167329	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	9642163	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	17264154	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	9642163	GOA
part of oligosaccharyltransferase complex	IPI IPI: Inferred from physical interaction	31831667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPN1 Protein Structure

Ribophorin_I

0
100
200
300
400
500
607 a.a.

Protein Preferred Names	Protein Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	RPN-I

RPN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPN1	P04843	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	RPN1	P04843	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	RPN1	P04843	MLEC	Homo sapiens	Q14165	Anti Tag CoIP	35271311
Intra	RPN1	P04843	MLEC	Homo sapiens	Q14165	Crosslink	30021884
Intra	RPN1	P04843	POMK	Homo sapiens	Q9H5K3	Anti Tag CoIP	32707033
Intra	RPN1	P04843	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	RPN1	P04843	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	RPN1	P04843	CAMLG	Homo sapiens	P49069	Y2H Array	32296183
Intra	RPN1	P04843	CAMLG	Homo sapiens	P49069	Y2H Prey Pooling	32296183
Intra	RPN1	P04843	CAMLG	Homo sapiens	P49069	Validated Y2H	32296183
Intra	RPN1	P04843	STT3B	Homo sapiens	Q8TCJ2	Anti Bait CoIP	19167329
Intra	RPN1	P04843	STT3B	Homo sapiens	Q8TCJ2	Anti Tag CoIP	35271311
Intra	RPN1	P04843	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	RPN1	P04843	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	RPN1	P04843	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	RPN1	P04843	STT3A	Homo sapiens	P46977	Anti Tag CoIP	35271311
Intra	RPN1	P04843	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Acute Myeloid Leukemia With Inv3(P21;Q26.2) Or T(3;3)(P21;Q26.2)	Aml With Inv(3)(Q21q26.2) Or T(3 3)(Q21 Q26.2) Acute Myeloid Leukemia With Inv(3)(Q21q26.2) Or T(3 3)(Q21 Q26.2) Aml With Inv3(P21 Q26.2) Or T(3 3)(P21 Q26.2) Aml With Inv3(Q21 Q26.2) Or T(3 3)(Q21 Q26.2) Acute Myeloid Leukemia With Inv3(Q21 Q26.2) Or T(3 3)(Q21 Q26.2)
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181098	FKA-9i		/	Unkown
HY-181495	RAJQ14	Degrader	/	Unkown
HY-RS11323	PSMD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12210	RPN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20337	Rpn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26845	Rpn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RPN1	VGNC	VGNC:76924
Rattus norvegicus	RPN1	RGD	RGD:3594
Canis familiaris	RPN1	VGNC	VGNC:45721
Felis catus	RPN1	VGNC	VGNC:64741
Mus musculus	RPN1	MGD	MGI:98084
Others	RPN1	NCBI