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Mitapivat hydrochloride

(Synonyms: AG-348 hydrochloride)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric pyruvate kinase R (PK-R) activator. Mitapivat hydrochloride accelerates the reaction of PK-R catalyzing the conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolytic pathway, increasing the production of adenosine triphosphate (ATP) in red blood cells, and reducing the level of 2,3-diphosphoglycerate (2,3-DPG). Mitapivat hydrochloride is promising for research of pyruvate kinase deficiency and other anemia-related diseases.

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  • CAS No.: 2559738-69-9
  • Formule: C24H27ClN4O3S
  • Masse moléculaire:487.01
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Mitapivat hydrochloride Chemical Structure
    Mitapivat hydrochloride Chemical Structure
  • Experimental Validation Results for Mitapivat hydrochloride
CAS No.: 2559738-69-9
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  • Mitapivat hydrochloride Chemical Structure
    Mitapivat hydrochloride Chemical Structure
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    Mitapivat hydrochloride purchased from MedChemExpress. Usage Cited in: Sep Sci Plus. 2025 Jan 07.

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     Mean plasma concentration–time profile and log-plasma concentration–time profile of Mitapivat after a single oral dose of 5 mg/kg to SD rats (each data point corresponds to mean ± S.D., n = 4).

  • Mitapivat hydrochloride