GABAB receptor stimulation phase-shifts the mammalian circadian clock in vitro

  • Brain Res. 1998 Oct 5;807(1-2):250-4. doi: 10.1016/s0006-8993(98)00820-8.
K R Biggs  1 ,  R A Prosser
Affiliations
  • 1. Department of Zoology, University of Tennessee, Knoxville, TN 37996, USA.
PMID: 9757057 DOI: 10.1016/s0006-8993(98)00820-8
Abstract

The mammalian circadian clock in the suprachiasmatic nucleus (SCN) generates 24-h rhythms in vitro. Here we show that the GABAB agonist baclofen resets the SCN pacemaker in vitro in a phase-dependent manner: advances were induced at zeitgeber time (ZT) 6, and delays were induced at ZT 22. Both effects were blocked the GABAB antagonist, 2-hydroxysaclofen, while the GABAA antagonist, bicuculline was ineffective. Thus, the SCN pacemaker is sensitive to resetting by GABAB stimulation.

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