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Cat. No.: HY-109041A

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Razuprotafib sodium

(Synonyms: AKB-9778 sodium)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib sodium promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib sodium inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib sodium shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM).

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CAS No.: 1809275-69-1
Formule: C₂₆H₂₅N₄NaO₆S₃
Masse moléculaire:608.68

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Data Sheet (273 KB)

Razuprotafib sodium Chemical Structure

CAS No.: 1809275-69-1

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Activité biologique
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- In Vivo
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Tie :

Tie1
Tie2

In Vitro

Razuprotafib (AKB-9778) sodium promotes TIE2 phosphorylation and activation of downstream signaling in HUVECs and enhances angiopoietin-induced TIE2 phosphorylation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Razuprotafib sodium (20 mg/kg; s.c.) promotes phosphorylation of TIE2 in retinal endothelial cells in vivo^[1]. Razuprotafib sodium (10-20 mg/kg; s.c.; twice daily for 7 days) suppresses subretinal neovascularization (NV)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1809275-69-1
Masse moléculaire 608.68
Formule C₂₆H₂₅N₄NaO₆S₃
SMILES

O=S(NC(C=C1)=CC=C1C[C@@H](C2=CSC(C3=CC=CS3)=N2)NC([C@@H](NC(OC)=O)CC4=CC=CC=C4)=O)(O[Na])=O
Synonyms

AKB-9778 sodium
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Exp Mol Med

An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone. [Abstract]

2023 Feb;55(2):470-484. PMID: 36828931
Int J Mol Sci

Razuprotafib Does Not Improve Microcirculatory Perfusion Disturbances nor Renal Edema in Rats on Extracorporeal Circulation. [Abstract]

2025 Mar 25;26(7):3000. PMID: 40243701
Int Immunopharmacol

Enhancing immunotherapy efficacy in oral cancer through AKB-9778-mediated vascular normalization. [Abstract]

2025 Jan 28:148:114133. PMID: 39879836
Research Square Print

August 19th, 2022.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Shen J, et al. Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. J Clin Invest. 2014;124(10):4564-4576. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Razuprotafib sodium

4 Cited Publications

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Razuprotafib sodium

Publications Citing Use of MedChemExpress (MCE) Razuprotafib sodium

Voir tous les produits spécifiques à Isoform Tie

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Publications (4)

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Razuprotafib sodium Related Classifications

HY-109041A Related Classifications