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Cat. No.: HY-107611

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Ro 24-5913

(Synonyms: Cinalukast)

Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC₅₀ value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 128312-51-6
Formule: C₂₃H₂₈N₂O₃S
Masse moléculaire:412.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ro 24-5913 Chemical Structure

CAS No.: 128312-51-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC₅₀ value of 6.4 nM. Ro 24-5913 can be used for the research of asthma^[1].

IC₅₀ & Target

IC50: 6.4 nM (LTD4)^[1]

Voir tous les produits spécifiques à Isoform Leukotriene Receptor :

In Vitro

Ro 24-5913 competes with [³H]LTD4 for its binding site in guinea pig lung membranes with an IC₅₀ value of 6.4 nM^[1].
Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pK_B value of 9.3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD₅₀s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Guinea pigs^[1]
Dosage:

10 mg/kg
Administration:

Oral gavage; 10 mg/kg once
Result:

Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.

Chemical Information

CAS No. 128312-51-6
Masse moléculaire 412.55
Formule C₂₃H₂₈N₂O₃S
SMILES

OC(C(CC)(CC)CC(NC1=CC=CC(/C=C/C2=NC(C3CCC3)=CS2)=C1)=O)=O
Synonyms

Cinalukast
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. O'Donnell M. Ro 24-5913: a potent, specific, orally active LTD4 antagonist. Ann N Y Acad Sci. 1991;629:413-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Ro 24-5913

Voir tous les produits spécifiques à Isoform Leukotriene Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Ro 24-5913 Related Classifications

HY-107611 Related Classifications