1075-06-5
Chemical Structure
2,2-Dihydroxy-1-phenylethan-1-one
Synonym(s): Phenylglyoxal hydrate
- CAS No.: 1075-06-5
- Formula:C8H8O3
- Molecular Weight:152.15
IUPAC Name: 2,2-dihydroxy-1-phenylethan-1-one
InChIKey: NBIBDIKAOBCFJN-UHFFFAOYSA-N
SMILES: OC(O)C(C1=CC=CC=C1)=O
Biological Activity: 2,2-Dihydroxy-1-phenylethan-1-one (Phenylglyoxal hydrate) is a phenylglyoxal-based, antioxidant drug synthesis intermediate. 2,2-Dihydroxy-1-phenylethan-1-one serves as a starting material for the synthesis of aromatic amines or aliphatic amines. It can be used to synthesize polysubstituted pyrrolo[3,2-c]pyridin-4-one derivatives, and also acts as a key structural unit in the microwave-assisted cascade synthesis of substituted 2-methyl-7-aryl-6H-thiazoloindole compounds[1][2][3].
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2,2-Dihydroxy-1-phenylethan-1-one | 97.0% | 2,2-Dihydroxy-1-phenylethan-1-one (Phenylglyoxal hydrate) is a phenylglyoxal-based, antioxidant drug synthesis intermediate. 2,2-Dihydroxy-1-phenylethan-1-one serves as a starting material for the synthesis of aromatic amines or aliphatic amines. It can be used to synthesize polysubstituted pyrrolo[3,2-c]pyridin-4-one derivatives, and also acts as a key structural unit in the microwave-assisted cascade synthesis of substituted 2-methyl-7-aryl-6H-thiazoloindole compounds. | ||||||||||||||||||||
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References
- [1]. Li C, et al. A multicomponent two-step strategy for the synthesis of polysubstituted pyrrolo [3, 2-c] pyridin-4-ones using a solid acid as a recyclable catalyst[J]. Green Chemistry, 2019, 21(11): 3109-3115.
- [2]. Wang J, et al. Cascade Construction of Diverse Thiazoloindoles via the Generation of New Indole Skeletons Under Microwave Irradiation[J]. Asian Journal of Organic Chemistry, 2026, 15(3): e70361.
- [3]. Tania Kundu, et al. Expeditious and eco-friendly synthesis of new multifunctionalized pyrrole derivatives and evaluation of their antioxidant property. Bioorg Chem. 2020 May;98:103734. [Content Brief]
